ArticleGenetics2011
Next-generation mapping of complex traits with phenotype-based selection and introgression.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Early life-stage thermal resilience is determined by climate-linked regulatory variation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genomic Islands of Divergence Between Drosophila yakuba Subspecies are Predominantly Driven by Chromosomal Inversions and the Recombination Landscape.Molecular ecology · 2025Article
- Identification and genetic analysis of a pervasive 'needle-eye' sperm phenotype inProceedings. Biological sciences · 2024Article
- Predicting the genomic resolution of bulk segregant analysis.G3 (Bethesda, Md.) · 2022Article
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- Drosophila yakuba mayottensis, a new model for the study of incipient ecological speciation.Fly · 2017Article
- Genetic Mapping by Bulk Segregant Analysis in Drosophila: Experimental Design and Simulation-Based Inference.Genetics · 2016Article
- Recurrent specialization on a toxic fruit in an island Drosophila population.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Higher-order genetic interactions and their contribution to complex traits.Trends in genetics : TIG · 2015Review
- Sequencing pools of individuals - mining genome-wide polymorphism data without big funding.Nature reviews. Genetics · 2014Review
- Large-scale identification of chemically induced mutations in Drosophila melanogaster.Genome research · 2014Article
- Causes and consequences of genetic background effects illuminated by integrative genomic analysis.Genetics · 2014Article
- Article
- Rapid genome wide mapping of phosphine resistance loci by a simple regional averaging analysis in the red flour beetle, Tribolium castaneum.BMC genomics · 2013Article
- Maximum likelihood estimation of frequencies of known haplotypes from pooled sequence data.Molecular biology and evolution · 2013Article
- The genetic architecture of a complex ecological trait: host plant use in the specialist moth, Heliothis subflexa.Evolution; international journal of organic evolution · 2012Article
- Investigating natural variation in Drosophila courtship song by the evolve and resequence approach.Genetics · 2012Article
- Article
Corrections and comments
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Finding the genes underlying complex traits is difficult. We show that new sequencing technology combined with traditional genetic techniques can efficiently identify genetic regions underlying a complex and quantitative behavioral trait. As a proof of concept we used phenotype-based introgression to backcross loci that control innate food preference in Drosophila simulans into the genomic background of D. sechellia, which expresses the opposite preference. We successfully mapped D. simulans introgression regions in a small mapping population (30 flies) with whole-genome resequencing using light coverage (∼1×). We found six loci contributing to D. simulans food preference, one of which overlaps a previously discovered allele. This approach is applicable to many systems, does not rely on laborious marker development or genotyping, does not require existing high quality reference genomes, and needs only small mapping populations. Because introgression is used, researchers can scale mapping population size, replication, and number of backcross generations to their needs. Finally, in contrast to more widely used mapping techniques like F(2) bulk-segregant analysis, our method produces near-isogenic lines that can be kept and reused indefinitely.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.