Evidence map›Paper›PMID 21940639›Full record

ArticleMolecular biology and evolution2012

Temporally variable selection on proteolysis-related reproductive tract proteins in Drosophila.

Alex Wong, Michael Turchin, Mariana F Wolfner, Charles F Aquadro

Open access · bronzeAbstract read
In one paragraph

Article in Molecular biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Nonadaptive molecular evolution of seminal fluid proteins in Drosophila.Evolution; international journal of organic evolution · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Alex WongDepartment of Molecular Biology and Genetics, Cornell University, USA. alex_wong@carleton.ca
Michael Turchin
Mariana F Wolfner
Charles F Aquadro
Cornell University · USCarleton University · CA

Funding

ACTIONS OF SEMINAL PROTEINS IN MATED DROSOPHILA FEMALESR01HD038921 · NICHD · CORNELL UNIVERSITY ITHACA · PI WOLFNER, MARIANA FEDERICA · 2000 to 2019
$5.6M
MOLECULAR POPULATION GENETICS OF DROSOPHILA MELANOGASTERR01GM036431 · NIGMS · CORNELL UNIVERSITY ITHACA · PI AQUADRO, CHARLES F · 1986 to 2010
$2.6M
Howard Hughes Medical InstituteNICHD NIH HHS R01 HD038921NICHD NIH HHS R01-HD038921NIGMS NIH HHS R01 GM036431NIGMS NIH HHS R01-GM036431
6 · The paper itself

Abstract

In order to gain further insight into the processes underlying rapid reproductive protein evolution, we have conducted a population genetic survey of 44 reproductive tract-expressed proteases, protease inhibitors, and targets of proteolysis in Drosophila melanogaster and Drosophila simulans. Our findings suggest that positive selection on this group of genes is temporally heterogeneous, with different patterns of selection inferred using tests sensitive at different time scales. Such variation in the strength and targets of selection through time may be expected under models of sexual conflict and/or host-pathogen interaction. Moreover, available functional information concerning the genes that show evidence of selection suggests that both sexual selection and immune processes have been important in the evolutionary history of this group of molecules.

Indexed as

Evolution, MolecularAmino Acid SubstitutionAnimalsDrosophilaFemaleGenetic VariationGenitaliaInsect ProteinsLinkage DisequilibriumMalePeptide HydrolasesProteolysisSelection, GeneticSpecies SpecificityInsect ProteinsPeptide Hydrolases

Identifiers

PMID21940639
PMCPMC3283112
OpenAlexW2102829943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.