ArticleNeurology2011
Arterial spin labeling and altered cerebral blood flow patterns in the minimally conscious state.
Article in Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Magnetic Resonance Imaging in Aneurysmal Subarachnoid Hemorrhage: Current Evidence and Future Directions.Neurocritical care · 2018Pooled it
- Arterial Spin Labeling of Cerebral Perfusion in Unresponsive Wakefulness Syndrome: A Proof-of-Concept Comparison with FDG-PET.Neurocritical care · 2026Article
- Neuroimaging of Disorder of Consciousness: From Brain Network Mechanisms to Clinical Translation.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Neurovascular Uncoupling in Alzheimer's and Parkinson's Diseases: Mechanisms and Therapeutic Strategies.Brain sciences · 2026Review
- Arterial Spin Labeling Magnetic Resonance Imaging for Acute Disorders of Consciousness in the Intensive Care Unit.Neurocritical care · 2024Article
- The effects of nicotine use during adolescence and young adulthood on gray matter cerebral blood flow estimates.Brain imaging and behavior · 2024Article
- Blood-brain barrier water exchange measurements using contrast-enhanced ASL.NMR in biomedicine · 2023Article
- Imaging Inflammation - From Whole Body Imaging to Cellular Resolution.Frontiers in immunology · 2021Review
- Complete hemispherotomy leads to lateralized functional organization and lower level of consciousness in the isolated hemisphere.Epilepsia open · 2020Article
- Uncovering Consciousness in Unresponsive ICU Patients: Technical, Medical and Ethical Considerations.Critical care (London, England) · 2019Review
- The Applicability of Amide Proton Transfer Imaging in the Nervous System: Focus on Hypoxic-Ischemic Encephalopathy in the Neonate.Cellular and molecular neurobiology · 2018Review
- Cerebral Blood Flow after Mild Traumatic Brain Injury: Associations between Symptoms and Post-Injury Perfusion.Journal of neurotrauma · 2018Article
- Could Arterial Spin Labeling Distinguish Patients in Minimally Conscious State from Patients in Vegetative State?Frontiers in neurology · 2018Article
- Default Mode Network Perfusion in Aneurysmal Subarachnoid Hemorrhage.Neurocritical care · 2016Article
- Mapping the Connectome Following Traumatic Brain Injury.Current neurology and neuroscience reports · 2016Review
- Quantitative research into the deconditioning of hemodynamic to disorder of consciousness carried out using transcranial Doppler ultrasonography and photoplethysmography obtained via finger-transmissive absorption.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- The application of a mathematical model linking structural and functional connectomes in severe brain injury.NeuroImage. Clinical · 2016Article
- A neuroradiologist's guide to arterial spin labeling MRI in clinical practice.Neuroradiology · 2015Review
- Disorders of consciousness after acquired brain injury: the state of the science.Nature reviews. Neurology · 2014Review
- Functional MRI and outcome in traumatic coma.Current neurology and neuroscience reports · 2013Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo use arterial spin labeling (ASL) to compare cerebral blood flow (CBF) patterns in minimally conscious state (MCS) patients with those in normal controls in an observational study design.
methodsSubjects meeting MCS criteria and normal controls were identified. A pseudocontinuous ASL sequence was performed with subjects and controls in the resting awake state. Multiple CBF values for 10 predetermined regions of interest were sampled and average CBF was calculated and compared between controls and subjects.
resultsTen normal controls were identified, with ages ranging from 26 to 54 years. Four subjects met the MCS criteria and received an ASL study, with one patient receiving a second study at a later date. Subjects ranged in age from 19 to 58 years and had traumatic brain injury, stroke, or hypoxic-ischemic encephalopathy. Regional CBF for controls ranged from 21.6 to 57.2 mL/100 g/min, with a pattern of relatively increased blood flow posteriorly including the posterior cingulate, parietal, and occipital cortices. CBF patterns for MCS subjects showed greater variability (from 7.7 to 33.1 mL/100 g/min), demonstrating globally decreased CBF in gray matter compared with that in normal controls, especially in the medial prefrontal and midfrontal regions. In the one subject studied longitudinally, global CBF values increased over time, which correlated with clinical improvement.
conclusionsWe identified globally decreased CBF and a selective reduction of CBF within the medial prefrontal and midfrontal cortical regions as well as gray matter in MCS patients. ASL may serve as an adjunctive method to assess functional reserve in patients recovering from severe brain injuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.