ArticleJournal of dental research2011
Effect of UVA-activated riboflavin on dentin bonding.
Article in Journal of dental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Effect of Dentin Biomodification on the Survival of Resin Composite Restorations: An Umbrella Review.International dental journal · 2026Pooled it
- Effect of diode laser irradiation (780-980 nm) on resin-dentin microtensile bond strength: a systematic review ofFrontiers in dental medicine · 2026Pooled it
- Pooled it
- Effect of collagen cross-linkers on dentin bond strength: A systematic review and network meta-analysis.Frontiers in bioengineering and biotechnology · 2022Pooled it
- Mechanisms regulating the degradation of dentin matrices by endogenous dentin proteases and their role in dental adhesion. A review.American journal of dentistry · 2014Pooled it
- MMP Inhibitors on Dentin Stability: A Systematic Review and Meta-analysis.Journal of dental research · 2014Pooled it
- Cause-Effect Relationship of Varying Bonding Thicknesses in Dentin Adhesion of Universal Adhesives.The journal of adhesive dentistry · 2022Trial
- Effects of Collagen Cross-Linking Agents on Dentin-Composite Interface Strength and Morphology.Calcified tissue international · 2026Article
- Evaluation of microtensile bond strength to dentin and adhesive layer thickness of a new generation two-bottle universal adhesive.European oral research · 2026Article
- The Impact of Antimicrobial Photodynamic Therapy (aPDT) with Various Photosensitizers on the Bond Strength of Orthodontic Brackets.Journal of lasers in medical sciences · 2026Article
- Durable Dentin Bonding with Multifunctional Methacrylated Proanthocyanidins.Journal of dental research · 2025Article
- Comparative In Vitro Study of Sol-Gel-Derived Bioactive Glasses Incorporated into Dentin Adhesives: Effects on Remineralization and Mechanical Properties of Dentin.Journal of functional biomaterials · 2025Article
- Use of Photoreactive Riboflavin and Blue Light Irradiation in Improving Dentin Bonding-Multifaceted Evaluation.Journal of functional biomaterials · 2025Article
- Riboflavin-ultraviolet-A collagen crosslinking treatments in improving dentin bonding and resistance to enzymatic digestion.Journal of dental sciences · 2025Article
- Current approaches to produce durable biomaterials: Trends in polymeric materials for restorative dentistry applications.Dental materials : official publication of the Academy of Dental Materials · 2024Review
- Evaluating the advancements in a recently introduced universal adhesive compared to its predecessor.Journal of dental sciences · 2024Article
- Impact of Dentine Pretreatment with Matrix Metalloproteinase Inhibitors on Bond Strength of Coronal Composite Restorations: A Systematic Review and Meta-analysis of In Vitro Studies.European journal of dentistry · 2023Article
- Crosslinking Improve Demineralized Dentin Performance and Synergistically Promote Biomimetic Mineralization by CaP_PILP.ACS omega · 2023Article
- Effects of Riboflavin Collagen Crosslinker on Dentin Adhesive Bonding Efficiency: A Systematic Review and Meta-Analysis.Materials (Basel, Switzerland) · 2023Review
- Mussel-inspired polymer with catechol and cationic Lys functionalities for dentin wet bonding.Materials today. Bio · 2023Article
Corrections and comments
- Commented on by
Authors and funding
11 authors.
Funding
Abstract
Recent studies have reported collagen cross-linking after exposure to riboflavin followed by ultraviolet-A (UVA) exposure. This study is the first to investigate the effect of a riboflavin-containing primer on adhesive interface stability and dentinal matrix metalloproteinase activity. Human dentin was etched with 35% phosphoric acid, treated with 0.1% riboflavin, exposed to UVA for 2 min, and bonded with a two-step etch-and-rinse adhesive. Adhesive was applied to control specimens without riboflavin/UVA. Specimens were subjected to microtensile bond strength tests and pulled to failure after storage for 24 hrs, 6 mos, or 1 yr. Interfacial nanoleakage was evaluated by light and transmission electron microscopy. To investigate dentinal matrix metalloproteinase activity, we performed correlative zymographic assays on protein extracts obtained from phosphoric-acid-etched dentin powder with or without riboflavin/UVA treatment and XP Bond. Ultraviolet-activated riboflavin treatment increased the immediate bond strength to dentin at all aging intervals (p < 0.05 vs. control) and decreased interfacial nanoleakage in aged specimens (1 yr; p < 0.05). Zymograms revealed that riboflavin/UVA pre-treatment inhibited dentinal matrix metalloproteinase activity (especially MMP-9). In conclusion, dentinal collagen cross-linking induced by riboflavin/UVA increased immediate bond strength, stabilized the adhesive interface, and inhibited dentin matrix metalloproteinases, thereby increasing the durability of resin-dentin bonds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.