ArticleProceedings of the National Academy of Sciences of the United States of America2011
Diverse factors are involved in maintaining X chromosome inactivation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
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- BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation.Nature communications · 2022Article
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- Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling.Developmental cell · 2020Article
- A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance.Journal of neurodevelopmental disorders · 2020Article
- CRISPR-assisted detection of RNA-protein interactions in living cells.Nature methods · 2020Article
- Varying levels of X chromosome coalescence in female somatic cells alters the balance of X-linked dosage compensation and is implicated in female-dominant systemic lupus erythematosus.Scientific reports · 2019Article
- Enjoy the silence: X-chromosome inactivation diversity in somatic cells.Current opinion in genetics & development · 2019Review
- Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Clinical Epigenetic Therapies Disrupt Sex Chromosome Dosage Compensation in Human Female Cells.Gender and the genome · 2018Article
- Progress in understanding the molecular mechanism ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication.Nucleic acids research · 2017Article
- A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Comparative sequence analyses of genome and transcriptome reveal novel transcripts and variants in the Asian elephant Elephas maximus.Journal of biosciences · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
X chromosome inactivation (XCI) is the most dramatic example of epigenetic silencing in eukaryotes. Once established, the inactivated X chromosome (Xi) remains silenced throughout subsequent cell divisions. Though the initiation of XCI has been studied extensively, the protein factors involved in Xi silencing and maintenance are largely unknown. Here we report the discovery of a diverse set of 32 proteins involved in maintenance of Xi silencing through a genome-wide RNAi screen. In addition, we describe the mechanistic roles of two proteins--origin recognition complex 2 (Orc2) and heterochromatin protein 1 (HP1α)--in Xi silencing. Immunofluorescence studies indicate that Orc2 and HP1α localize on Xi in mouse cells. Depletion of Orc2 by shRNA leads to the loss of both Orc2 and HP1α localization on Xi. Furthermore, the silencing of genes on Xi is disrupted in both Orc2- and HP1α-depleted cells. Finally, we show, using ChIP assay, that the localization of HP1α and Orc2 to the promoter regions of Xi-silenced genes is interdependent. These findings reveal a diverse set of proteins involved in Xi silencing, show how Orc2 and HP1α impact Xi silencing, and provide a basis for future studies on the maintenance of Xi silencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.