ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Differentially organized top-down modulation of prepulse inhibition of startle.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 65 citations in OpenAlex.
- Functional near-infrared spectroscopy to probe state- and trait-like conditions in chronic tinnitus: a proof-of-principle study.Neural plasticity · 2014Trial
- Distal pup cues attenuate defensive reactivity and fear-potentiated startle magnitude in postpartum rats without altering sensorimotor gating.Behavioral neuroscience · 2026Article
- From hidden hearing loss to supranormal auditory processing by neurotrophin 3-mediated modulation of inner hair cell synapse density.PLoS biology · 2024Article
- Elucidation of the mechanism underlying impaired sensorimotor gating in patients with primary blepharospasm using prepulse inhibition.Frontiers in neurology · 2023Article
- Prepulse inhibition predicts subjective hearing in rats.Scientific reports · 2021Article
- Effects of prepulse format and lead interval on the assessment of automatic and attention-modulated prepulse inhibition.Cognitive processing · 2021Article
- Neuropeptide S-Mediated Modulation of Prepulse Inhibition Depends on Age, Gender, Stimulus-Timing, and Attention.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Involvement of the thalamic reticular nucleus in prepulse inhibition of acoustic startle.Translational psychiatry · 2021Article
- Looming Effects on Attentional Modulation of Prepulse Inhibition Paradigm.Frontiers in psychology · 2021Article
- Neural Correlates of Attentional Modulation of Prepulse Inhibition.Frontiers in human neuroscience · 2021Article
- Habituation of auditory startle reflex is a new sign of minimally conscious state.Brain : a journal of neurology · 2020Article
- Fear leads to a deficit of prepulse inhibition of blink reflex in healthy humans.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Neural correlates of perceptual separation-induced enhancement of prepulse inhibition of startle in humans.Scientific reports · 2018Article
- Sensorimotor Gating in Depressed and Euthymic Patients with Bipolar Disorder: Analysis on Prepulse Inhibition of Acoustic Startle Response Stratified by Gender and State.Frontiers in psychiatry · 2018Article
- Tinnitus and hyperacusis: Contributions of paraflocculus, reticular formation and stress.Hearing research · 2017Article
- Different effects of isolation-rearing and neonatal MK-801 treatment on attentional modulations of prepulse inhibition of startle in rats.Psychopharmacology · 2016Article
- Prepulse inhibition of the acoustic startle reflex vs. auditory brainstem response for hearing assessment.Hearing research · 2016Article
- Behavioral and pharmacological validation of an integrated fear-potentiated startle and prepulse inhibition paradigm.Behavioural brain research · 2016Article
- Benefits of Stimulus Exposure: Developmental Learning Independent of Task Performance.Frontiers in neuroscience · 2016Article
- The Functional Networks of Prepulse Inhibition: Neuronal Connectivity Analysis Based on FDG-PET in Awake and Unrestrained Rats.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prepulse inhibition (PPI) of startle is the suppression of the startle reflex when a weaker sensory stimulus (the prepulse) shortly precedes the startling stimulus. PPI can be attentionally enhanced in both humans and laboratory animals. This study investigated whether the following three forebrain structures, which are critical for initial cortical processing of auditory signals, auditory fear conditioning/memories, and spatial attention, respectively, play a role in the top-down modulation of PPI in rats: the primary auditory cortex (A1), lateral nucleus of the amygdala (LA), and posterior parietal cortex (PPC). The results show that, under the noise-masking condition, PPI was enhanced by fear conditioning of the prepulse in a prepulse-specific manner, and the conditioning-induced PPI enhancement was further increased by perceptual separation between the conditioned prepulse and the noise masker. Reversibly blocking glutamate receptors in the A1 with 2 mm kynurenic acid eliminated both the conditioning-induced and perceptual separation-induced PPI enhancements. Blocking the LA eliminated the conditioning-induced but not the perceptual separation-induced PPI enhancement, and blocking the PPC specifically eliminated the perceptual separation-induced PPI enhancement. The two types of PPI enhancements were also eliminated by the extinction manipulation. Thus, the top-down modulation of PPI is differentially organized and depends on operations of various forebrain structures. Due to the fine-tuned modulation by higher-order cognitive processes, functions of PPI can be more flexible to complex environments. The top-down enhancements of PPI in rats are also useful for modeling some mental disorders, such as schizophrenia, attention deficit/hyperactivity disorder, and posttraumatic stress disorder.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.