ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Complementary function and integrated wiring of the evolutionarily distinct Drosophila olfactory subsystems.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 284 papers.
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Who cites it
284 citing papers in PubMed, 517 citations in OpenAlex.
- Identification of markers facilitating the study of support cells in adult olfactory sensilla in Drosophila.Insect biochemistry and molecular biology · 2026Article
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- Odorant receptor coexpression and multi-expression in the dengue mosquito.Nature communications · 2026Article
- Beat- and Side-family cell-surface molecules are expressed combinatorially in the partner neurons of the olfactory circuit in Drosophila.PLoS biology · 2026Article
- Noses on the wing: the olfactory capacity of hawkmoth wings.The Journal of experimental biology · 2026Article
- Genome-Wide Identification and Characterization of Chemosensory Gene Families in the MayflyGenes · 2026Article
- The Sensory Basis of Planarian Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Receptor sequence divergence, gain, loss, duplication, and neofunctionalization drive olfactory adaptation inProceedings of the National Academy of Sciences of the United States of America · 2026Article
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- IR25a-like Receptors are Required for Olfactory Detection of Plant Volatiles in the Carmine Spider Mite.Journal of chemical ecology · 2026Article
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- Hawkmoths can smell with grooming organs on their legs.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Multimodal social context modulates larval behavior inScience advances · 2026Article
- The sensory gene repertoire of deep-sea hydrothermal shrimp.PloS one · 2026Article
- Convergence-divergence circuits for multimodal integration of innate and learned opponent valences.Frontiers in systems neuroscience · 2026Article
- Multilayer regulation underlies the functional precision and evolutionary potential of the olfactory system.Nature communications · 2025Article
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- An Orco dependent pathway suppresses egg-laying attraction to ripe fruit volatile compounds in Drosophila melanogaster but not in D. suzukii.BMC ecology and evolution · 2025Article
- Genetic variation in olfactory pathways associated with host-seeking behavior in natural populations of Anopheles minimus, a primary malaria vector in western Thailand.Parasites & vectors · 2025Article
- Extinction of Innate Floral Preferences in the Generalist Solitary Pollinator Eristalis tenax.Journal of chemical ecology · 2025Article
224 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
Abstract
To sense myriad environmental odors, animals have evolved multiple, large families of divergent olfactory receptors. How and why distinct receptor repertoires and their associated circuits are functionally and anatomically integrated is essentially unknown. We have addressed these questions through comprehensive comparative analysis of the Drosophila olfactory subsystems that express the ionotropic receptors (IRs) and odorant receptors (ORs). We identify ligands for most IR neuron classes, revealing their specificity for select amines and acids, which complements the broader tuning of ORs for esters and alcohols. IR and OR sensory neurons exhibit glomerular convergence in segregated, although interconnected, zones of the primary olfactory center, but these circuits are extensively interdigitated in higher brain regions. Consistently, behavioral responses to odors arise from an interplay between IR- and OR-dependent pathways. We integrate knowledge on the different phylogenetic and developmental properties of these receptors and circuits to propose models for the functional contributions and evolution of these distinct olfactory subsystems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.