ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Opioidergic interactions between striatal projection neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- The NK1 antagonist L-733,060 facilitates sequence learning.Journal of psychopharmacology (Oxford, England) · 2023Article
- Angiotensin-converting enzyme gates brain circuit-specific plasticity via an endogenous opioid.Science (New York, N.Y.) · 2022Article
- Prenatal opioid exposure reprograms the behavioural response to future alcohol reward.Addiction biology · 2022Article
- Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain.Frontiers in molecular neuroscience · 2022Review
- Article
- Mu opioid receptors on vGluT2-expressing glutamatergic neurons modulate opioid reward.Addiction biology · 2021Article
- Recent Progress in Opioid Research from an Electrophysiological Perspective.Molecular pharmacology · 2020Review
- Compartmental function and modulation of the striatum.Journal of neuroscience research · 2019Review
- Reduced nucleus accumbens enkephalins underlie vulnerability to social defeat stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Opioidergic Modulation of Striatal Circuits, Implications in Parkinson's Disease and Levodopa Induced Dyskinesia.Frontiers in neurology · 2018Review
- Endogenous opioids regulate moment-to-moment neuronal communication and excitability.Nature communications · 2017Article
- Striatal Neuropeptides Enhance Selection and Rejection of Sequential Actions.Frontiers in computational neuroscience · 2017Article
- Dichotomous Effects of Mu Opioid Receptor Activation on Striatal Low-Threshold Spike Interneurons.Frontiers in cellular neuroscience · 2017Article
- Genetic-Based Dissection Unveils the Inputs and Outputs of Striatal Patch and Matrix Compartments.Neuron · 2016Article
- Mutual Control of Cholinergic and Low-Threshold Spike Interneurons in the Striatum.Frontiers in cellular neuroscience · 2016Article
- Enkephalin Disinhibits Mu Opioid Receptor-Rich Striatal Patches via Delta Opioid Receptors.Neuron · 2015Article
- The role of δ-opioid receptors in learning and memory underlying the development of addiction.British journal of pharmacology · 2015Review
- Presynaptic Inhibition in the Striatum of the Basal Ganglia Improves Pattern Classification and Thus Promotes Superior Goal Selection.Frontiers in systems neuroscience · 2015Review
- Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking.British journal of pharmacology · 2015Article
- Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum.Nature neuroscience · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Medium spiny striatal projection neurons (MSNs) release opioid neuropeptides, but the role of these neurotransmitters is still poorly understood. While presynaptic inhibition of corticostriatal axons by opioid receptors has been demonstrated using exogenous ligands, the action of synaptically released opioids in the striatum has not been investigated. We performed single and paired whole-cell recordings from rat MSNs while corticostriatal fibers were electrically activated. In single recording experiments, we also activated antidromically the axons of a population of MSNs. Corticostriatal fibers were stimulated once every 10 s and every other stimulation was preceded by 5 antidromic spikes (at 100 Hz). This burst of antidromic spikes produced robust inhibition of evoked corticostriatal responses. This inhibition was not affected by the δ-opioid receptor antagonist SDM25N, but was completely abolished by the μ-opioid receptor antagonist CTOP. Inhibitory effects were maximal (on average 29.6 ± 11.4%) when the burst preceded the corticostriatal stimulation by 500 ms and became undetectable for intervals >2 s. Paired recordings from MSNs located <100 μm apart revealed that, in 30 of 56 (54%) pairs, a burst of five action potentials in one of the MSNs caused significant inhibition (17.1 ± 5.7%) of evoked glutamatergic responses in the other MSN. In 5 of these pairs, reciprocal inhibition of corticostriatal inputs was present. These effects were maximal 500 ms after the burst and were completely blocked by CTOP. Thus, these results reveal a novel, strong opioid-mediated communication between MSNs and provide a new cellular substrate for competitive dynamics in the striatum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.