Evidence map›Paper›PMID 21940196›Full record

ReviewDrug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy2011

Slipping and sliding: frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance.

Anthony Griffiths

Abstract readReview
In one paragraph

Review in Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Alphaherpesvirus Genomics: Past, Present and Future.Current issues in molecular biology · 2021
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Anthony GriffithsDepartment of Virology and Immunology, Texas Biomedical Research Institute and Southwest National Primate Research Center, 7620 N.W. Loop 410, San Antonio, TX 78227, USA. agriffiths@txbiomed.org

Funding

WNV REPLIVAX VACCINE IN NON-HUMAN PRIMATESP51RR013986 · NCRR · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI GAUDUIN, MARIE-CLAIRE ELISABETH · 1999 to 2011
$79.1M
Development of a Vaccine to Protect Monkeys from Herpes B Virus InfectionR21RR026287 · NCRR · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI GRIFFITHS, ANTHONY · 2011 to 2011
$219k
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR012087 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI VANDEBERG, JOHN L · 1996 to 1996
–
NCRR NIH HHS C06 RR012087NCRR NIH HHS P51 RR013986NCRR NIH HHS R21 RR026287
6 · The paper itself

Abstract

Some of the most successful antiviral agents currently available are effective against herpes simplex virus. However, resistance to these drugs is frequently associated with significant morbidity, particularly in immunocompromised patients. In addition to the clinical implications of drug resistance, the range of biological processes exploited by the virus to attain resistance while maintaining pathogenicity is proving to be surprising. These mechanisms, which include ribosomal frameshifting, induced infidelity of the DNA polymerase, and internal ribosome entry, are discussed.

Indexed as

AnimalsAntiviral AgentsDNA-Directed DNA PolymeraseDrug Resistance, ViralExodeoxyribonucleasesFrameshift MutationHerpes SimplexHumansImmunocompromised HostSimplexvirusThymidine KinaseViral ProteinsAntiviral AgentsDNA-Directed DNA PolymeraseDNA polymerase, SimplexvirusExodeoxyribonucleasesThymidine KinaseViral Proteins

Identifiers

PMID21940196
PMCPMC3195865

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.