ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2011
Building conditions, 5-HTTLPR genotype, and depressive symptoms in adolescent males and females.
Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Gender Differences in Depression: Evidence From Genetics.Frontiers in genetics · 2020Review
- The Serotonin Transporter Promoter Variant, Stress, and Attentional Biases in Middle Childhood.Personality and individual differences · 2016Article
- Gene-by-social-environment interaction (GxSE) between ADCYAP1R1 genotype and neighborhood crime predicts major depression symptoms in trauma-exposed women.Journal of affective disorders · 2015Article
- Life events, genetic susceptibility, and smoking among adolescents.Social science research · 2015Article
- Depressogenic vulnerability and gender-specific patterns of neuro-immune dysregulation: What the ratio of cortisol to C-reactive protein can tell us about loss of normal regulatory control.Brain, behavior, and immunity · 2015Article
- The Involvement of Genes in Adolescent Depression: A Systematic Review.Frontiers in behavioral neuroscience · 2015Review
- Genotype by environment interaction and neurodevelopment III. Focus on the child's broader social ecology.Epidemiology and psychiatric sciences · 2013Article
- 5-HTTLPR X stress in adolescent depression: moderation by MAOA and gender.Journal of abnormal child psychology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeEmerging work suggests that both environmental and genetic factors contribute to risk of depression in adolescents, and that these factors may differ between genders. We assessed whether features of the social environment (SE), measured at varying levels, and genetic factors jointly contribute to the risk of depression in adolescent males and females.
methodsUsing data from a national survey of U.S. adolescents, we applied cross-sectional, multilevel mixed models to assess the contribution of: (i) 5-HTTLPR genotype and respondent-level building conditions to depressive symptom score (DSS); and (ii) 5-HTTLPR genotype and neighborhood-level building conditions to DSS. Models testing potential gene-SE interactions were also conducted. All models were stratified by gender and adjusted for age, race/ethnicity, family structure, parental education, and social support.
resultsAmong females, adjusted analyses indicated that sl genotype carriers enjoyed a marginally significant (p = .07) protective effect against higher DSS in models assessing respondent-level building conditions. In contrast, among males, adjusted analyses predicted significantly higher DSS for residents of neighborhoods with relatively poor building conditions (p < .01). No significant gene-SE interactions were detected for either gender.
conclusionsThese results suggest that adverse, macro-level SE factors increase risk of depression to a greater extent in adolescent males than in females. Intervention strategies designed to improve mental health in adolescent populations should consider a growing body of work suggesting that the contextual factors conferring increased risk of depression differ among males and females.
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