Evidence map›Paper›PMID 21939841›Full record

ReviewNeurosurgery clinics of North America2011

Electrical stimulation for epilepsy: experimental approaches.

John D Rolston, Sharanya Arcot Desai, Nealen G Laxpati, Robert E Gross

Abstract readReview
In one paragraph

Review in Neurosurgery clinics of North America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Invasive Neuromodulation for the Treatment of Pediatric Epilepsy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019
    Review
  9. Closed-Loop Brain Stimulation for Drug-Resistant Epilepsy: Towards an Evidence-Based Approach to Personalized Medicine.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019
    Review
  10. Article
  11. Article
  12. Article
  13. Deep brain stimulation for the treatment of epilepsy: circuits, targets, and trials.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014
    Review
  14. Article
  15. Neuromodulation for brain disorders: challenges and opportunities.IEEE transactions on bio-medical engineering · 2013
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

John D RolstonDepartment of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA.
Sharanya Arcot Desai
Nealen G Laxpati
Robert E Gross

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
TRAINING IN TRANSLATIONAL RESEARCH IN NEUROLOGYT32NS007480 · NINDS · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 2000 to 2020
$4.5M
Axon Guidance Molecules in Nigrostriatal RegenerationK08NS046322 · NINDS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 2004 to 2009
$842k
Distributed microstimulation for epilepsyR21NS054809 · NINDS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 2008 to 2009
$372k
Closed-loop distributed microstimulation for epilepsyF30NS060392 · NINDS · EMORY UNIVERSITY · PI ROLSTON, JOHN D · 2008 to 2010
$80k
NIGMS NIH HHS GM08169NIGMS NIH HHS T32 GM008169NINDS NIH HHS F30 NS060392NINDS NIH HHS K08 NS046322NINDS NIH HHS NS007480NINDS NIH HHS NS046322NINDS NIH HHS NS054809NINDS NIH HHS NS060392NINDS NIH HHS R21 NS054809NINDS NIH HHS T32 NS007480
6 · The paper itself

Abstract

Direct electrical stimulation of the brain is an increasingly popular means of treating refractory epilepsy. Although there has been moderate success in human trials, the rate of seizure freedom does not yet compare favorably to resective surgery. It therefore remains critical to advance experimental investigations aimed toward understanding brain stimulation and its utility. This article introduces the concepts necessary for understanding these experimental studies, describing recording and stimulation technology, animal models of epilepsy, and various subcortical targets of stimulation. Bidirectional and closed-loop device technologies are also highlighted, along with the challenges presented by their experimental use.

Indexed as

AnimalsBrainDeep Brain StimulationDisease Models, AnimalEpilepsyHumansMicroelectrodes

Identifiers

PMID21939841
PMCPMC3190668

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.