Evidence map›Paper›PMID 21939829›Full record

Trial reportJournal of the American College of Cardiology2011

Education, income, and incident heart failure in post-menopausal women: the Women's Health Initiative Hormone Therapy Trials.

Rashmee U Shah, Marilyn A Winkleby, Linda Van Horn, Lawrence S Phillips, Charles B Eaton, Lisa W Martin, Milagros C Rosal, Joann E Manson, Hongyan Ning, Donald M Lloyd-Jones and 1 more

Abstract readComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American College of Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Sex-Specific Outcomes in Cardiovascular Device Evaluations.Journal of women's health (2002) · 2020
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rashmee U ShahDepartment of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. rashmee.shah@cshs.org
Marilyn A Winkleby
Linda Van Horn
Lawrence S Phillips
Charles B Eaton
Lisa W Martin
Milagros C Rosal
Joann E Manson
Hongyan Ning
Donald M Lloyd-Jones
Liviu Klein

Funding

Women's Health Initiative Memory Study (WHIMS)N01WH44221 · WH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2009 to 2010
$3.1M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042119 · WH · YESHIVA UNIVERSITY · PI WASSERTHEIL-SMOLLER, SYLVIA · 1994 to 2001
$2.2M
Stanford Center for Clinical and Translational Education and Research (SCCTER)KL2KL2RR025743 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$1.9M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032101 · WH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GRIMM, RICHARD H · 1993 to 2000
$1.7M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032111 · WH · EMORY UNIVERSITY · PI WATTS, NELSON · 1993 to 2001
$1.6M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042123 · WH · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042109 · WH · STANFORD UNIVERSITY · PI STEFANICK, MARCIA L · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042114 · WH · KAISER FOUNDATION RESEARCH INSTITUTE · PI RITENBAUGH, CHERYL K · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042108 · WH · GEORGE WASHINGTON UNIVERSITY · PI HSIA, JUDITH · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042124 · WH · RUSH UNIVERSITY MEDICAL CENTER · PI BLACK, HENRY R · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042131 · WH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI O'SULLIVAN, MARY J · 1994 to 2000
$1.3M
WOMENS HEALTH INITIATIVE-N01WH22110N01WH022110 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ROSS, PRENTICE · 1992 to 2006
$1.2M
NCRR NIH HHS KL2 RR025743NCRR NIH HHS KL2RR025743NIA NIH HHS R21 AG027471NIA NIH HHS R21AG027471WHI NIH HHS N01 WH022110WHI NIH HHS N01WH24152WHI NIH HHS N01WH32100WHI NIH HHS N01WH32101WHI NIH HHS N01WH32102WHI NIH HHS N01WH32105WHI NIH HHS N01WH32106WHI NIH HHS N01WH32108WHI NIH HHS N01WH32109WHI NIH HHS N01WH32111WHI NIH HHS N01WH32112WHI NIH HHS N01WH32113WHI NIH HHS N01WH32115WHI NIH HHS N01WH32118WHI NIH HHS N01WH32119WHI NIH HHS N01WH32122WHI NIH HHS N01WH42107WHI NIH HHS N01WH42108WHI NIH HHS N01WH42109WHI NIH HHS N01WH42110WHI NIH HHS N01WH42111WHI NIH HHS N01WH42112WHI NIH HHS N01WH42113WHI NIH HHS N01WH42114WHI NIH HHS N01WH42115WHI NIH HHS N01WH42116WHI NIH HHS N01WH42117WHI NIH HHS N01WH42118WHI NIH HHS N01WH42119WHI NIH HHS N01WH42120WHI NIH HHS N01WH42121WHI NIH HHS N01WH42122WHI NIH HHS N01WH42123WHI NIH HHS N01WH42124WHI NIH HHS N01WH42125WHI NIH HHS N01WH42126WHI NIH HHS N01WH42129WHI NIH HHS N01WH42130WHI NIH HHS N01WH42131WHI NIH HHS N01WH42132WHI NIH HHS N01WH44221
6 · The paper itself

Abstract

objectivesThe purpose of this study is to estimate the effect of education and income on incident heart failure (HF) hospitalization among post-menopausal women.

backgroundInvestigations of socioeconomic status have focused on outcomes after HF diagnosis, not associations with incident HF. We used data from the Women's Health Initiative Hormone Trials to examine the association between socioeconomic status levels and incident HF hospitalization.

methodsWe included 26,160 healthy, post-menopausal women. Education and income were self-reported. Analysis of variance, chi-square tests, and proportional hazards models were used for statistical analysis, with adjustment for demographics, comorbid conditions, behavioral factors, and hormone and dietary modification assignments.

resultsWomen with household incomes <$20,000 a year had higher HF hospitalization incidence (57.3/10,000 person-years) than women with household incomes >$50,000 a year (16.7/10,000 person-years; p < 0.01). Women with less than a high school education had higher HF hospitalization incidence (51.2/10,000 person-years) than college graduates and above (25.5/10,000 person-years; p < 0.01). In multivariable analyses, women with the lowest income levels had 56% higher risk (hazard ratio: 1.56, 95% confidence interval: 1.19 to 2.04) than the highest income women; women with the least amount of education had 21% higher risk for incident HF hospitalization (hazard ratio: 1.21, 95% confidence interval: 0.90 to 1.62) than the most educated women.

conclusionsLower income is associated with an increased incidence of HF hospitalization among healthy, post-menopausal women, whereas multivariable adjustment attenuated the association of education with incident HF.

Indexed as

IncomePostmenopauseAgedEducational StatusEstrogen Replacement TherapyFemaleFollow-Up StudiesHeart FailureHumansIncidenceMiddle Aged

Identifiers

PMID21939829
PMCPMC3635103

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.