ArticleBone2012
Short-term physical activity intervention decreases femoral bone marrow adipose tissue in young children: a pilot study.
Article in Bone, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Plyometric exercise and bone health in children and adolescents: a systematic review.World journal of pediatrics : WJP · 2017Pooled it
- Effects of Exercise on Bone Marrow Adipose Tissue in Children With Overweight/Obesity: Role of Liver Fat.The Journal of clinical endocrinology and metabolism · 2025Trial
- Function and Regulation of Bone Marrow Adipose Tissue in Health and Disease: State of the Field and Clinical Considerations.Comprehensive Physiology · 2024Review
- The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation.Cell & bioscience · 2021Review
- Fat and bone: the multiperspective analysis of a close relationship.Quantitative imaging in medicine and surgery · 2020Review
- Bone marrow fat fraction assessment in regard to physical activity: KORA FF4-3-T MR imaging in a population-based cohort.European radiology · 2020Article
- Medium-Intensity Treadmill Exercise Exerts Beneficial Effects on Bone Modeling Through Bone Marrow Mesenchymal Stromal Cells.Frontiers in cell and developmental biology · 2020Article
- Bone Marrow Adiposity: Basic and Clinical Implications.Endocrine reviews · 2019Review
- Bone Health and Its Relationship with Impact Loading and the Continuity of Physical Activity throughout School Periods.International journal of environmental research and public health · 2019Article
- Review
- Clinical implications of bone marrow adiposity.Journal of internal medicine · 2018Review
- Physical Signals May Affect Mesenchymal Stem Cell Differentiation via Epigenetic Controls.Exercise and sport sciences reviews · 2018Review
- Mechanisms of marrow adiposity and its implications for skeletal health.Metabolism: clinical and experimental · 2017Review
- Actin up in the Nucleus: Regulation of Actin Structures Modulates Mesenchymal Stem Cell Differentiation.Transactions of the American Clinical and Climatological Association · 2017Article
- Segmentation and quantification of adipose tissue by magnetic resonance imaging.Magma (New York, N.Y.) · 2016Review
- Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Article
- Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals.Journal of clinical & translational endocrinology · 2015Article
- Marrow fat and bone--new perspectives.The Journal of clinical endocrinology and metabolism · 2013Review
- The relationships among total body fat, bone mineral content and bone marrow adipose tissue in early-pubertal girls.BoneKEy reports · 2013Article
- Comparison among T1-weighted magnetic resonance imaging, modified dixon method, and magnetic resonance spectroscopy in measuring bone marrow fat.Journal of obesity · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Mechanical stimulation is necessary for maximization of geometrical properties of bone mineralization contributing to long-term strength. The amount of mineralization in bones has been reciprocally related to volume of bone marrow adipose tissue and this relationship is suggested to be an independent predictor of fracture. Physical activity represents an extrinsic factor that impacts both mineralization and marrow volume exerting permissive capacity of the growing skeleton to achieve its full genetic potential. Because geometry- and shape-determining processes primarily manifest during the linear growth period, the accelerated structural changes accompanying early childhood (ages 3 to 6 y) may have profound impact on lifelong bone health. The objective of this pilot study was to determine if a short-term physical activity intervention in young children would result in augmentation of geometric properties of bone. Three days per week the intervention group (n=10) participated in 30 min of moderate intensity physical activity, such as jumping, hopping and running, and stretching activities, whereas controls (n=10) underwent usual activities during the 10-week intervention period. Femoral bone marrow adipose tissue volume and total body composition were assessed by magnetic resonance imaging and dual-energy X-ray absorptiometry, respectively, at baseline and after 10 weeks. Although after 10-weeks, intergroup differences were not observed, a significant decrease in femoral marrow adipose tissue volume was observed in those participating in physical activity intervention. Our findings suggest that physical activity may improve bone quality via antagonistic effects on femoral bone marrow adipose tissue and possibly long-term agonistic effects on bone mineralization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.