ArticleNeuroscience letters2011
Function of prostaglandin E2 EP receptors in the acute outcome of rodent hypoxic ischemic encephalopathy.
Article in Neuroscience letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Chorioamnionitis, Inflammation and Neonatal Apnea: Effects on Preterm Neonatal Brainstem and on Peripheral Airways: Chorioamnionitis and Neonatal Respiratory Functions.Children (Basel, Switzerland) · 2021Review
- A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition.Neurobiology of disease · 2020Review
- Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1β in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis.International journal of molecular sciences · 2018Article
- The Consequences of Preterm Birth and Chorioamnionitis on Brainstem Respiratory Centers: Implications for Neurochemical Development and Altered Functions by Inflammation and Prostaglandins.Frontiers in cellular neuroscience · 2018Review
- Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4⁺ T Cells through IL-1β Autocrine Function in Experimental Autoimmune Encephalomyelitis.International journal of molecular sciences · 2017Article
- Anti-Inflammatory and Neuroprotective Effects of PGEJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2017Article
- Cerebroprotection by the neuronal PGE2 receptor EP2 after intracerebral hemorrhage in middle-aged mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Preclinical Studies and Translational Applications of Intracerebral Hemorrhage.BioMed research international · 2017Review
- Misoprostol Reverse Hippocampal Neuron Cyclooxygenase-2 Downstream Signaling Imbalance in Aluminum-Overload Rats.Current Alzheimer research · 2016Article
- Intracerebral hemorrhage outcomes following selective blockade or stimulation of the PGE2 EP1 receptor.BMC neuroscience · 2015Article
- Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus.Neuropharmacology · 2015Article
- PGE2 receptor agonist misoprostol protects brain against intracerebral hemorrhage in mice.Neurobiology of aging · 2015Article
- Protection by vascular prostaglandin E2 signaling in hypoxic-ischemic encephalopathy.Experimental neurology · 2014Article
- Post-ischemic inflammation regulates neural damage and protection.Frontiers in cellular neuroscience · 2014Review
- Endogenous protection derived from activin A/Smads transduction loop stimulated via ischemic injury in PC12 cells.Molecules (Basel, Switzerland) · 2013Article
- Lack of evidence for neonatal misoprostol neurodevelopmental toxicity in C57BL6/J mice.PloS one · 2012Article
- Putative role of prostaglandin receptor in intracerebral hemorrhage.Frontiers in neurology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Neonatal hypoxic-ischemic encephalopathy (HIE) is a leading cause of severe and permanent neurologic disability after birth. The inducible cyclooxygenase COX-2, which along with COX-1 catalyzes the first committed step in prostaglandin (PG) synthesis, elicits significant brain injury in models of cerebral ischemia; however its downstream PG receptor pathways trigger both toxic and paradoxically protective effects. Here, we investigated the function of PGE(2) E-prostanoid (EP) receptors in the acute outcome of hypoxic-ischemic (HI) injury in the neonatal rat. We determined the temporal and cellular expression patterns of the EP1-4 receptors before and after HIE and tested whether modulation of EP1-4 receptor function could protect against cerebral injury acutely after HIE. All four EP receptors were expressed in forebrain neurons and were induced in endothelial cells after HIE. Inhibition of EP1 signaling with the selective antagonist SC-51089 or co-activation of EP2-4 receptors with the agonist misoprostol significantly reduced HIE cerebral injury 24 h after injury. These receptor ligands also protected brain endothelial cells subjected to oxygen glucose deprivation, suggesting that activation of EP receptor signaling is directly cytoprotective. These data indicate that the G-protein coupled EP receptors may be amenable to pharmacologic targeting in the acute setting of neonatal HIE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.