ReviewMolecular and cellular endocrinology2012
Circadian system, sleep and endocrinology.
Review in Molecular and cellular endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
175 citing papers in PubMed, 7 syntheses or guidelines pooled it, 386 citations in OpenAlex.
- Biological rhythms in premenstrual syndrome and premenstrual dysphoric disorder: a systematic review.BMC women's health · 2024Pooled it
- Social jetlag and dietary intake: A systematic review.Sleep medicine reviews · 2023Pooled it
- Best Time of Day for Strength and Endurance Training to Improve Health and Performance? A Systematic Review with Meta-analysis.Sports medicine - open · 2023Pooled it
- Potential of Polyphenols for Improving Sleep: A Preliminary Results from Review of Human Clinical Trials and Mechanistic Insights.Nutrients · 2023Pooled it
- Sleep duration and risk of hyperlipidemia: a systematic review and meta-analysis of prospective studies.Sleep & breathing = Schlaf & Atmung · 2022Pooled it
- The Impact of Shift-Work and Night Shift-Work on Thyroid: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- Long-Term Sleep Duration as a Risk Factor for Breast Cancer: Evidence from a Systematic Review and Dose-Response Meta-Analysis.BioMed research international · 2017Pooled it
- Quantification of the endogenous growth hormone and prolactin lowering effects of a somatostatin-dopamine chimera using population PK/PD modeling.Journal of pharmacokinetics and pharmacodynamics · 2020Trial
- Circadian misalignment increases cardiovascular disease risk factors in humans.Proceedings of the National Academy of Sciences of the United States of America · 2016Trial
- Effects of the Internal Circadian System and Circadian Misalignment on Glucose Tolerance in Chronic Shift Workers.The Journal of clinical endocrinology and metabolism · 2016Trial
- The Human Circadian System Has a Dominating Role in Causing the Morning/Evening Difference in Diet-Induced Thermogenesis.Obesity (Silver Spring, Md.) · 2015Trial
- Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans.Proceedings of the National Academy of Sciences of the United States of America · 2015Trial
- Sleep architecture when sleeping at an unusual circadian time and associations with insulin sensitivity.PloS one · 2013Trial
- Trial
- Disrupted daily rhythms in light exposure and wrist temperature are associated with metabolic risk markers and obesity.International journal of obesity (2005) · 2026Article
- BMAL1 Dysregulation as a Contributing Mechanism Linking Obesity to Oocyte and Endometrial Dysfunction in IVF.International journal of molecular sciences · 2026Review
- The role of sleep disorders in orchestrating proteomic dysfunction and multi-morbidity.Molecular psychiatry · 2026Review
- Sleep regularity, circadian rhythms, and chronotype as mechanisms of risk for affective dysregulation in female adolescents.Development and psychopathology · 2026Article
- Article
- Investigation of stress hormones across multiday seizure cycles.Brain communications · 2026Article
115 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Levels of numerous hormones vary across the day and night. Such fluctuations are not only attributable to changes in sleep/wakefulness and other behaviors but also to a circadian timing system governed by the suprachiasmatic nucleus of the hypothalamus. Sleep has a strong effect on levels of some hormones such as growth hormone but little effect on others which are more strongly regulated by the circadian timing system (e.g., melatonin). Whereas the exact mechanisms through which sleep affects circulating hormonal levels are poorly understood, more is known about how the circadian timing system influences the secretion of hormones. The suprachiasmatic nucleus exerts its influence on hormones via neuronal and humoral signals but it is now also apparent that peripheral tissues contain circadian clock proteins, similar to those in the suprachiasmatic nucleus, that are also involved in hormone regulation. Under normal circumstances, behaviors and the circadian timing system are synchronized with an optimal phase relationship and consequently hormonal systems are exquisitely regulated. However, many individuals (e.g., shift-workers) frequently and/or chronically undergo circadian misalignment by desynchronizing their sleep/wake and fasting/feeding cycle from the circadian timing system. Recent experiments indicate that circadian misalignment has an adverse effect on metabolic and hormonal factors such as circulating glucose and insulin. Further research is needed to determine the underlying mechanisms that cause the negative effects induced by circadian misalignment. Such research could aid the development of novel countermeasures for circadian misalignment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.