ArticleVaccine2011
Viral interference induced by live attenuated virus vaccine (OPV) can prevent otitis media.
Article in Vaccine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Non-specific effects of Pneumococcal and Haemophilus vaccines in children aged 5 years and under: a systematic review.BMJ open · 2023Pooled it
- Vaccination With Oral Polio Vaccine Reduces COVID-19 Incidence.Frontiers in immunology · 2022Trial
- Interference Between Respiratory Syncytial Virus and Human Rhinovirus Infection in Infancy.The Journal of infectious diseases · 2017Trial
- Trial
- Trial
- Trial
- Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Trial
- Advances and challenges in poliomyelitis vaccines: a comprehensive review of development, production, and global deployment.Frontiers in public health · 2025Review
- A Risk Management Approach to Global Pandemics of Infectious Disease and Anti-Microbial Resistance.Tropical medicine and infectious disease · 2024Review
- Investigating Nonspecific Effects of the Live-Attenuated Japanese Encephalitis Vaccine on Lower Respiratory Tract Infections in Children Aged 25-35 Months: Retrospective Cohort Study.JMIR public health and surveillance · 2024Article
- Silent neonatal influenza A virus infection primes systemic antimicrobial immunity.Frontiers in immunology · 2023Article
- Oral Polio Vaccine to Mitigate the Risk of Illness and Mortality During the Coronavirus Disease 2019 Pandemic: A Cluster-Randomized Trial in Guinea-Bissau.Open forum infectious diseases · 2022Article
- Review
- Heterologous vaccination interventions to reduce pandemic morbidity and mortality: Modeling the US winter 2020 COVID-19 wave.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infants.Frontiers in microbiology · 2022Article
- Oral Polio Vaccine Campaigns May Reduce the Risk of Death from Respiratory Infections.Vaccines · 2021Article
- Racing to immunity: Journey to a COVID-19 vaccine and lessons for the future.British journal of clinical pharmacology · 2021Review
- National immunisation campaigns with oral polio vaccine may reduce all-cause mortality: Analysis of 2004-2019 demographic surveillance data in rural Bangladesh.EClinicalMedicine · 2021Article
- Heterologous vaccine interventions: boosting immunity against future pandemics.Molecular medicine (Cambridge, Mass.) · 2021Review
- A Health Economic Analysis for Oral Poliovirus Vaccine to Prevent COVID-19 in the United States.Risk analysis : an official publication of the Society for Risk Analysis · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe goal of this study was to evaluate whether a live attenuated poliovirus vaccine (OPV) has clinically relevant interfering effect with non-polio infections causing otitis media in young children.
methodsOpen trial in which the intervention group (64 children) received OPV at the age of 2, 3, 6 and 12 months. The control group (250 children) received IPV (inactivated polio vaccine) at the age of 6 and 12 months. Clinical symptoms were recorded by a questionnaire at the age of 3, 6, 12, 18 and 24 months.
resultsOtitis media episodes were less frequent in the OPV than in the control group. A significant difference was seen at the age of 6-18 months (IRR=0.76 [95% CI 0.59-0.94], P=0.011) and was particularly clear among children, who attended daycare (IRR 0.37 [95% CI 0.19-0.71], P=0.003).
conclusionsOPV provides some protection against otitis media. This effect may be mediated by viral interference with non-polio viruses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.