Evidence map›Paper›PMID 21939506›Full record

ArticleMalaria journal2011

The parasite clearance curve.

N J White

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01736319 (Artemisinin-resistant Plasmodium Falciparum Malaria in Cambodia), which is not on this map. Cited by 127 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01736319 completednot on this mapstarted 2012, after this paper: background citation

Artemisinin-resistant Plasmodium Falciparum Malaria in Cambodia

TypeobservationalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran2012 to 2016Enrolled561ConditionsPlasmodium Falciparum Malaria
3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  17. Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria.The New England journal of medicine · 2016
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67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

N J WhiteMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. nickw@tropmedres.ac

Funding

Wellcome Trust 093956
6 · The paper itself

Abstract

Parasite clearance rates are important measures of anti-malarial drug efficacy. They are particularly important in the assessment of artemisinin resistance. The slope of the log-linear segment in the middle of the parasite clearance curve has the least inter-individual variance and is the focus of therapeutic assessment. The factors affecting parasite clearance are reviewed. Methods of presentation and the approaches to analysis are discussed.

Indexed as

AntimalarialsArtemisininsDrug MonitoringHumansLactonesMalariaParasitemiaPlasmodiumAntimalarialsartemisinArtemisininsLactones

Identifiers

PMID21939506
PMCPMC3195204

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.