ArticleAntioxidants & redox signaling2012
Systemic redox regulation of cellular information processing.
Article in Antioxidants & redox signaling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Can thiol-based redox systems be utilized as parts for synthetic biology applications?Redox report : communications in free radical research · 2021Article
- Redox Systems Biology: Harnessing the Sentinels of the Cysteine Redoxome.Antioxidants & redox signaling · 2020Review
- Single-cell resolution of intracellular T cell CaIntegrative biology : quantitative biosciences from nano to macro · 2017Article
- Dynamic Redox Regulation of IL-4 Signaling.PLoS computational biology · 2015Article
- Elements of the cellular metabolic structure.Frontiers in molecular biosciences · 2015Article
- The Redox System in C. elegans, a Phylogenetic Approach.Journal of toxicology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Receptor-mediated signaling leads to transient changes in redox state, resulting in reversible oxidation of protein cysteine thiols. Numerous signaling proteins have been identified as being redox sensitive; however, to date, most investigations have focused on the ramifications of isolated protein modifications on cellular phenotypes. We propose that reversible thiol oxidation of proteins in a signaling network and their systemic interactions introduce features in the dynamics and control of cellular responses that are unique compared with isolated oxidative protein modifications. Simulations of dynamic redox regulation in different cellular contexts reveal feasible regulatory features for future experimental investigation. We suggest that location within a network, compartmentalization, and the degree of connectivity between redox proteins can dramatically modulate cellular information processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.