ArticleDigestive diseases and sciences2012
Risk of ulcerative colitis-associated colorectal cancer in China: a multi-center retrospective study.
Article in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Risk of colorectal cancer in Asian patients with ulcerative colitis: a systematic review and meta-analysis.The lancet. Gastroenterology & hepatology · 2017Pooled it
- Pooled it
- 5-Aminosalicylates reduce the risk of colorectal neoplasia in patients with ulcerative colitis: an updated meta-analysis.PloS one · 2014Pooled it
- An epithelial mesenchymal transition associated gene signature stratifies risk of ulcerative colitis associated colorectal cancer.Discover oncology · 2026Article
- Clinical Characteristics, Management, and Outcomes of Colitis-Associated Colorectal Cancer and the Comparison With Sporadic Colorectal Cancer in Taiwan.Clinical and translational gastroenterology · 2025Article
- Update and latest advances in mechanisms and management of colitis-associated colorectal cancer.World journal of gastrointestinal oncology · 2023Review
- Recent advances in surveillance colonoscopy for dysplasia in inflammatory bowel disease.Clinical endoscopy · 2022Review
- Natural history of inflammatory bowel disease: a comparison between the East and the West.Intestinal research · 2022Review
- Identification of hub genes and pathways in colitis-associated colon cancer by integrated bioinformatic analysis.BMC genomic data · 2022Article
- From inflammatory bowel disease to colorectal cancer: what's the role of miRNAs?Cancer cell international · 2022Review
- Chromoendoscopy with targeted biopsies is superior to white-light endoscopy for the long-term follow-up detection of dysplasia in ulcerative colitis patients: a multicenter randomized-controlled trial.Gastroenterology report · 2021Article
- The Effects of Sishen Wan on T Cell Responses in Mice Models of Ulcerative Colitis Induced by Dextran Sodium Sulfate.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Oral Nanoparticles of SNX10-shRNA Plasmids Ameliorate Mouse Colitis.International journal of nanomedicine · 2021Article
- Risk factors for colorectal neoplasia in patients with underlying inflammatory bowel disease: a multicenter study.Gastroenterology report · 2019Article
- Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis.Gastroenterology research and practice · 2019Article
- How Does the Epidemiology of Inflammatory Bowel Disease Differ between East and West? A Korean Perspective.Inflammatory intestinal diseases · 2017Review
- Long-term follow-up reveals high incidence of colorectal cancer in Indian patients with inflammatory bowel disease.United European gastroenterology journal · 2017Article
- Predicting Outcomes to Optimize Disease Management in Inflammatory Bowel Diseases.Journal of Crohn's & colitis · 2016Article
- Chitooligosaccharides promote radiosensitivity in colon cancer line SW480.World journal of gastroenterology · 2016Article
- Risk factors for developing colorectal cancer in Japanese patients with ulcerative colitis: a retrospective observational study-CAPITAL (Cohort and Practice for IBD total management in Kyoto-Shiga Links) study I.BMJ open gastroenterology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe number of patients with ulcerative colitis (UC) in China has increased in the past 10 years. Thus, it is anticipated that the incidence of UC-associated colorectal cancer (UC-CRC) will also increase. However, the risk of CRC in UC patients is still unknown in Chinese. The aim of this study was to identify the risk and risk factors of UC-CRC in Chinese.
methodsA total of 3,922 patients with UC were retrospectively collected from five central teaching hospitals in China, in which high-quality endoscopic and histological diagnoses were available from 1998 to 2009. The database of the UC and UC-associated CRC patients was evaluated.
resultsCRC was diagnosed 34 in patients, and the overall prevalence of CRC in patients with UC was 0.87%. The cumulative risk of developing CRC after a disease duration of 10 years was 1.15% (95% confidence interval [CI] 0.71-1.84%); 20 years, 3.56% (95% CI 2.14-5.89%); and 30 years, 14.36% (95% CI 7.57-26.3%). Longer disease duration, extensive colitis, and dysplasia found in the biopsy specimen were identified as risk factors for developing CRC. 5-ASA use was identified as a protective factor of UC-CRC.
conclusionsThe period prevalence of CRC was lower than that reported from the West. However, the cumulative risk was found to be comparable to that of Western countries, which suggests that the period prevalence of UC-CRC in China may be growing in the future.
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