ArticleInflammation2012
Investigation into the anti-inflammatory and antigranuloma activity of Colchicum luteum Baker in experimental models.
Article in Inflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Bioactivity Assessment and In Silico Target Engagement ofFood science & nutrition · 2026Article
- Investigation of Analgesic, Anti-Inflammatory, and Thrombolytic Effects of Methanolic Extract and Its Fractions ofMolecules (Basel, Switzerland) · 2025Article
- Article
- In Vivo Anti-Inflammatory and Antinociceptive Activities of Black Elder (Pharmaceuticals (Basel, Switzerland) · 2024Article
- Metals-triggered compound CDPDP exhibits anti-arthritic behavior by downregulating the inflammatory cytokines, and modulating the oxidative storm in mice models with extensive ADMET, docking and simulation studies.Frontiers in pharmacology · 2022Article
- Chemical Profiling and Biological Properties of Extracts from Different Parts ofAntioxidants (Basel, Switzerland) · 2019Article
- Anti-Inflammation Effect of Small Molecule Oligopeptides Prepared fromMolecules (Basel, Switzerland) · 2019Article
- Antioxidant and anti-inflammatory activities of ethyl acetate extract ofExperimental and therapeutic medicine · 2017Article
- Cat's whiskers (Orthosiphon stamineus) tea modulates arthritis pathogenesis via the angiogenesis and inflammatory cascade.BMC complementary and alternative medicine · 2016Article
- Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis.Rheumatology international · 2015Review
- Anti-granuloma activity of Coriandrum sativum in experimental models.Journal of Ayurveda and integrative medicine · 2013Article
- Anti-inflammatory and antiarthritic activity of UNIM-301 (a polyherbal unani formulation) in Wistar rats.Pharmacognosy researchArticle
- Article
- Design and development of Unani anti-inflammatory cream.Journal of Ayurveda and integrative medicineArticle
- Anti-inflammatory and anti-granuloma activity of Berberis aristata DC. in experimental models of inflammation.Indian journal of pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study evaluates the anti-inflammatory and antigranuloma activity of CLHE in experimental models, viz. carrageenan-induced paw edema, subcutaneous cotton pellet implantation-induced granuloma formation, and complete Freund's adjuvant-induced stimulation of peritoneal macrophages in rats. Serum TNF-alpha, IL-6, and IL-1 beta levels were estimated as markers for global effects of inflammation. TNF-R1 protein expression was estimated in stimulated peritoneal macrophages. There was a significant reduction (P < 0.05) of paw edema in the CLHE-treated groups as compared to control. In the cotton pellet-induced granuloma model, there was a significant (P < 0.05) reduction in the dry granuloma weight and serum TNF-alpha, IL-6, and IL-1beta levels in the CLHE-treated group as compared to control. Immunoblot analysis for TNF-R1 also demonstrated a significant reduction in the receptor protein expression on stimulated macrophages. Result of the present study thus demonstrates and validates the antigranuloma activity of CLHE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.