ArticleMolecular and cellular biochemistry2012
The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells.
Article in Molecular and cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Insights on the Role of Polyphenols in Combating Cancer Drug Resistance.Biomedicines · 2023Review
- Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect.Drug delivery · 2020Article
- Expression of genes and proteins of multidrug resistance in gastric cancer cells treated with resveratrol.Oncology letters · 2018Article
- Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition.Molecules (Basel, Switzerland) · 2017Review
- Polyphenols and DNA Damage: A Mixed Blessing.Nutrients · 2016Review
- Single cell measurement of telomerase expression and splicing using microfluidic emulsion cultures.Nucleic acids research · 2015Article
- Effect of curcumin on human colon cancer multidrug resistance in vitro and in vivo.Clinics (Sao Paulo, Brazil) · 2013Article
- Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.Frontiers in microbiology · 2012Article
- Furanodiene induces endoplasmic reticulum stress and presents antiproliferative activities in lung cancer cells.Evidence-based complementary and alternative medicine : eCAM · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anti-cancer activities of curcumin (CUR), a polyphenol derived from the plant Curcuma longa, has been extensively studied. In the present study, we found that CUR displayed anti-multidrug-resistant (MDR) activity in K562/A02 cells. A short-time treatment with CUR sufficiently and equally induced DNA damage, decreased cell viability, and triggered apoptosis in parent K562 and MDR K562/A02 cells. The short-time treatment with CUR also caused decrease of pro-caspase 3 in both cell lines and decrease of pro-caspase 9, increase of PARP cleavage and the ratio of Bax/Bcl-xL in MDR K562/A02 cells. Further experiment revealed that CUR was capable of down-regulating P-glycoprotein in MDR K562/A02 cells. Moreover, we observed that Cu(2+) enhanced CUR-mediated apoptosis which was blocked by antioxidants N-acetyl-cysteine and catalase. In summary, the short-time treatment with CUR sufficiently induced DNA damage, decreased cell viability and triggered apoptosis in MDR K562/A02 cells and Cu(2+) enhanced CUR-mediated apoptosis which due to reactive oxygen species generation.
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