Trial reportPrimary care respiratory journal : journal of the General Practice Airways Group2012
Feasibility and acceptability of using bronchial hyperresponsiveness to manage asthma in primary care: a pilot study.
Trial report in Primary care respiratory journal : journal of the General Practice Airways Group, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Trial
- The use of a direct bronchial challenge test in primary care to diagnose asthma.NPJ primary care respiratory medicine · 2020Observational
- Practical approach to exercise-induced bronchoconstriction in athletes.Primary care respiratory journal : journal of the General Practice Airways Group · 2013Article
- Asthma monitoring in primary care: time to gather more robust evidence.Primary care respiratory journal : journal of the General Practice Airways Group · 2012Article
- Airway hyperresponsiveness in asthma: mechanisms, clinical significance, and treatment.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine if indirect testing for bronchial hyperresponsiveness (BHR) to monitor inhaled corticosteroid (ICS) treatment in asthma is feasible and acceptable in primary care.
methodsFourteen adult patients with asthma aged 22-70 years (4M:10F, forced expiratory volume in 1 s >70% predicted) taking ICS performed a test for BHR using mannitol on three visits 6 weeks apart. ICS dose adjustments were made based on the presence of BHR. The Asthma Quality of Life Questionnaire (AQLQ) and the Asthma Control Questionnaire were used at each visit. A semi structured interview at study exit assessed subject acceptability.
resultsBHR did not return in those with no BHR at study entry (n=9) with decreasing ICS dose. Improvements in BHR with increasing ICS dose (n=5) were observed with clinically significant improvements in AQLQ (mean score increase >0.5, p=0.02). Feasibility and acceptability of BHR testing was demonstrated.
conclusionsIt is feasible and acceptable to perform BHR testing using mannitol to help identify patients with asthma who would benefit from ICS dose increases and those with no BHR who could have a dose reduction.
trial registrationAustralia New Zealand Clinical Trial Registry ACTRN12610000807055.
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