Evidence map›Paper›PMID 21938285›Full record

ArticleOrganic & biomolecular chemistry2011

Polymorphism and resolution of oncogene promoter quadruplex-forming sequences.

M Clarke Miller, Huy T Le, William L Dean, Patrick A Holt, Jonathan B Chaires, John O Trent

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Thermally Induced Transitions of d(GLife (Basel, Switzerland) · 2022
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M Clarke MillerDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.
Huy T Le
William L Dean
Patrick A Holt
Jonathan B Chaires
John O Trent

Funding

PROJ 12: STEM CELL-BASED VACCINE FOR CANCER PROPHYLAXISP20RR018733 · NCRR · UNIVERSITY OF LOUISVILLE · PI TRENT, JOHN O · 2003 to 2011
$18.9M
Targeting Nucleic Acids with an Integrated Vitural and Actual ScreenR01GM077422 · NIGMS · UNIVERSITY OF LOUISVILLE · PI CHAIRES, JONATHAN B., TRENT, JOHN O · 2007 to 2020
$3.7M
Development of Nucleolin targeted Anticancer CompoundsR01CA113735 · NCI · UNIVERSITY OF LOUISVILLE · PI TRENT, JOHN O · 2005 to 2009
$1.3M
NCI NIH HHS CA113735-01NCI NIH HHS R01 CA113735NCRR NIH HHS P20 RR018733NCRR NIH HHS P20RR018733NIGMS NIH HHS R01 GM077422
6 · The paper itself

Abstract

We report the separation of several quadruplex species formed by ten promoter sequences by Size Exclusion Chromatography (SEC). Modification at the 5' or 3' ends or in loop regions of quadruplex forming sequences has become the standard technique for dealing with quadruplex polymorphism. However, conformations produced employing this method or by other means of artificially shifting the equilibrium may not represent the species that are present in vivo. This method enables an unperturbed view of the structural polymorphism inherent to quadruplex formation. Separation via SEC facilitates studies on quadruplex structure and biophysical properties without the need for sequence modification.

Indexed as

G-QuadruplexesPromoter Regions, GeneticChemistry, OrganicChromatography, GelCircular DichroismDNAGuanineHumansMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPolymorphism, GeneticProto-OncogenesDNAGuanine

Identifiers

PMID21938285
PMCPMC3962748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.