ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2001
The modelling of a primitive 'sustainable' conservative cell.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Analysing and simulating energy-based models in biology using BondGraphTools.The European physical journal. E, Soft matter · 2021Article
- Reproducibility in Computational Neuroscience Models and Simulations.IEEE transactions on bio-medical engineering · 2016Article
- Interpreting genetic effects through models of cardiac electromechanics.American journal of physiology. Heart and circulatory physiology · 2012Review
- Modeling to link regional myocardial work, metabolism and blood flows.Annals of biomedical engineering · 2012Review
- Mechanical changes in the rat right ventricle with decellularization.Journal of biomechanics · 2012Article
- Cooperativity and specificity in enzyme kinetics: a single-molecule time-based perspective.Biophysical journal · 2008Article
- Simultaneous blood-tissue exchange of oxygen, carbon dioxide, bicarbonate, and hydrogen ion.Annals of biomedical engineering · 2006Article
- Strategies and Tactics in Multiscale Modeling of Cell-to-Organ Systems.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2006Article
- A biophysical model of the mitochondrial respiratory system and oxidative phosphorylation.PLoS computational biology · 2005Article
- Multiscale modeling of cardiac cellular energetics.Annals of the New York Academy of Sciences · 2005Review
- The computational integrated myocyte: a view into the virtual heart.Annals of the New York Academy of Sciences · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The simple sustainable or 'eternal' cell model, assuming preservation of all proteins, is designed as a building block, a primitive element upon which one can build more complete functional cell models of various types, representing various species. In the modelling we emphasize the electrophysiological aspects, in part because these are a well-developed component of cell models and because membrane potentials and their fluctuations have been generally omitted from metabolically oriented cell models in the past. Fluctuations in membrane potential deserve heightened consideration because probably all cells have negative intracellular potentials and most cells demonstrate electrical activity with vesicular extrusion, receptor occupancy, as well as with stimulated excitation resulting in regenerative depolarization. The emphasis is on the balances of mass, charge, and of chemical species while accounting for substrate uptake, metabolism and metabolite loss from the cell. By starting with a primitive representation we emphasize the conservation ideas. As more advanced models are generated they must adhere to the same basic principles as are required for the most primitive incomplete model.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.