ArticleMolecules (Basel, Switzerland)2011
Solid-phase synthesis of a new diphosphate 5-aminoimidazole-4-carboxamide riboside (AICAR) derivative and studies toward cyclic AICAR diphosphate ribose.
Article in Molecules (Basel, Switzerland), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes.Chembiochem : a European journal of chemical biology · 2025Review
- Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex.Pharmaceutics · 2020Article
- New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with CaMarine drugs · 2019Article
- Crystal structure of an ep-oxy-sterol: 9α,11α-ep-oxy-5α-cholest-7-ene-3β,5,6α-triol 3,6-di-acetate.Acta crystallographica. Section E, Crystallographic communications · 2017Article
- Crystal structure of a new spiro-polytetra-hydro-furan compound with translational pseudosymmetry:Acta crystallographica. Section E, Crystallographic communications · 2017Article
- 5-Amino-1-(2',3'-Acta crystallographica. Section E, Crystallographic communications · 2017Article
- Synthesis of cyclic N (1)-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells.Beilstein journal of organic chemistry · 2015Article
- Synthesis and pharmacological evaluation of modified adenosines joined to mono-functional platinum moieties.Molecules (Basel, Switzerland) · 2014Article
- Synthesis of new acadesine (AICA-riboside) analogues having acyclic D-ribityl or 4-hydroxybutyl chains in place of the ribose.Molecules (Basel, Switzerland) · 2013Article
- A facile synthesis of 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR): a novel non-phosphorylable AICAR analogue.Molecules (Basel, Switzerland) · 2012Article
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8 authors.
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Abstract
The solid-phase synthesis of the first example of a new diphosphate AICAR derivative is reported. The new substance is characterized by the presence of a 5'-phosphate group while a second phosphate moiety is installed on a 5-hydroxypentyl chain attached to the 4-N-position of AICAR. Cyclization of the diphosphate derivative by pyrophosphate bond formation allowed for the formation of a novel AICAR-based cyclic ADP-ribose (cADPR) mimic.
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