ArticleJournal of neuropathology and experimental neurology2011
Late development of the GABAergic system in the human cerebral cortex and white matter.
Article in Journal of neuropathology and experimental neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
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Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Aperiodic and Hurst EEG exponents across early human brain development: A systematic review.Developmental cognitive neuroscience · 2024Pooled it
- A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR.Scientific reports · 2021Trial
- Translational Initiative to Minimize Childhood Hemiparesis After Asymmetrical Perinatal Brain Injury.Bioengineering (Basel, Switzerland) · 2026Article
- Brain metabolite changes in neonates of mothers with SARS-CoV-2 infection during pregnancy: a case-control study.Pediatric radiology · 2026Article
- Characterization of aperiodic and theta activity in preterm infants using EEG: Insights into cerebral maturation and inter-individual variability.Developmental cognitive neuroscience · 2026Article
- Impact of prenatal exposure to airborne particulate matter on local functional connections in the cerebral cortex of neonates.NeuroImage · 2026Article
- From womb to words: the sex-specific interplay of fetal sex hormones and maternal mood on infant language development.Frontiers in endocrinology · 2026Article
- The indirect pathway hypothesis of schizophrenia: insights from perinatal asphyxia.Frontiers in physiology · 2026Review
- Bilingual Exposure and Sex Shape Developmental Trajectories of Brain Responses to Speech-Sound Features in Infants.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Impact of Prenatal Alcohol Exposure on the Cerebral Circulation: Potential Implications for Stroke.Advances in experimental medicine and biology · 2026Review
- The association between infant EEG aperiodic exponent and the trajectory of restricted and repetitive behaviors for toddlers with and without autism.Journal of neurodevelopmental disorders · 2025Article
- General anesthesia in early infancy accelerates visual cortical development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- Auditory evoked delta brushes involve stimulus-specific cortical networks in preterm infants.iScience · 2025Article
- Beyond motor learning: Insights from infant magnetic resonance imaging on the critical role of the cerebellum in behavioral development.Developmental cognitive neuroscience · 2025Review
- Mechanisms of brain overgrowth in autism spectrum disorder with macrocephaly.Frontiers in neuroscience · 2025Review
- The link between non-human primate vocalizations and cognition is not constrained by maturation alone: Evidence from healthy preterm infants.Cognition · 2024Article
- Sedation and anesthesia for imaging of the infant and neonate-a brief review.Pediatric radiology · 2024Review
- Epigenetic insights into GABAergic development in Dravet Syndrome iPSC and therapeutic implications.eLife · 2024Article
- In vivo neural regeneration via AAV-NeuroD1 gene delivery to astrocytes in neonatal hypoxic-ischemic brain injury.Inflammation and regeneration · 2024Article
22 more citing papers are in PubMed but not listed here.
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9 authors.
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Abstract
Despite the key role of γ-aminobutyric acid (GABA) neurons in the modulation of cerebral cortical output, little is known about their development in the human cortex. We analyzed several GABAergic parameters in standardized regions of the cerebral cortex and white matter in a total of 38 human fetuses and infants from 19 gestational weeks to 2.7 postnatal years using immunocytochemistry, Western blotting, tissue autoradiography, and computer-based cellular quantitation. At least 20% of GABAergic neurons in the white matter migrated toward the cortex over late gestation. After term, migration declined and ended within 6 postnatal months. In parallel, the GABAergic neuronal density increased in the cortex over late gestation, also with a peak at term. From midgestation to infancy, the pattern of GABAA receptor binding changed from uniformly low across all cortical layers to high levels concentrated in the middle laminae; glutamic acid decarboxylase (GAD65 and GAD67) levels differentially increased. Thus, the second half of gestation is a period of rapid development of the cortical GABAergic system that continues into early infancy. This period corresponds to the peak window of vulnerability to perinatal hypoxia-ischemia in which GABAergic neurons are potentially developmentally susceptible, including in the preterm infant.
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