ArticleMolecular biology of the cell2011
Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet).
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 48 citations in OpenAlex.
- Recovery from spindle checkpoint-mediated arrest requires a novel Dnt1-dependent APC/C activation mechanism.PLoS genetics · 2022Article
- Insulin receptor endocytosis in the pathophysiology of insulin resistance.Experimental & molecular medicine · 2020Review
- APC/C: current understanding and future perspectives.F1000Research · 2019Review
- Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13.Nature · 2018Article
- Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Mapping Mitotic Death: Functional Integration of Mitochondria, Spindle Assembly Checkpoint and Apoptosis.Frontiers in cell and developmental biology · 2018Review
- Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing.Nature communications · 2017Article
- Taming the Beast: Control of APC/CCold Spring Harbor symposia on quantitative biology · 2017Article
- LOVTRAP: an optogenetic system for photoinduced protein dissociation.Nature methods · 2016Article
- Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.Molecular cell · 2016Article
- Article
- Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability.Nature communications · 2016Article
- The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Nature communications · 2016Article
- The mitotic checkpoint complex (MCC): looking back and forth after 15 years.AIMS molecular science · 2016Article
- Spatiotemporal regulation of the anaphase-promoting complex in mitosis.Nature reviews. Molecular cell biology · 2015Review
- The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis.The Journal of biological chemistry · 2015Article
- Phosphorylation of Xenopus p31(comet) potentiates mitotic checkpoint exit.Cell cycle (Georgetown, Tex.) · 2015Article
- Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation.The EMBO journal · 2014Article
- Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein.The Journal of biological chemistry · 2014Article
- Phosphorylation regulates the p31Comet-mitotic arrest-deficient 2 (Mad2) interaction to promote spindle assembly checkpoint (SAC) activity.The Journal of biological chemistry · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The spindle checkpoint senses unattached or improperly attached kinetochores during mitosis, inhibits the anaphase-promoting complex or cyclosome (APC/C), and delays anaphase onset to prevent aneuploidy. The mitotic checkpoint complex (MCC) consisting of BubR1, Bub3, Mad2, and Cdc20 is a critical APC/C-inhibitory checkpoint complex in human cells. At the metaphase-anaphase transition, the spindle checkpoint turns off, and MCC disassembles to allow anaphase onset. The molecular mechanisms of checkpoint inactivation are poorly understood. A major unresolved issue is the role of Cdc20 autoubiquitination in this process. Although Cdc20 autoubiquitination can promote Mad2 dissociation from Cdc20, a nonubiquitinatable Cdc20 mutant still dissociates from Mad2 during checkpoint inactivation. Here, we show that depletion of p31(comet) delays Mad2 dissociation from Cdc20 mutants that cannot undergo autoubiquitination. Thus both p31(comet) and ubiquitination of Cdc20 are critical mechanisms of checkpoint inactivation. They act redundantly to promote Mad2 dissociation from Cdc20.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.