ArticleThe Journal of clinical endocrinology and metabolism2011
Polymorphisms in the neuropeptide Y gene and the risk of obesity: findings from two prospective cohorts.
Article in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 41 citations in OpenAlex.
- Neuropeptide Y genotype, central obesity, and abdominal fat distribution: the POUNDS LOST trial.The American journal of clinical nutrition · 2015Trial
- Leptin Receptor (rs1137101) and Brain-Derived Neurotrophic Factor (rs925946) Gene Variants Are Associated with Obesity in the Early- but Not in the Late-Onset Population of Hungarian Psoriatic Patients.Life (Basel, Switzerland) · 2021Article
- Relation of neuropeptide Y gene expression and genotyping with hypertension in chronic kidney disease.Biochemistry and biophysics reports · 2019Article
- A Review of Single-Nucleotide Polymorphisms in Orexigenic Neuropeptides Targeting G Protein-Coupled Receptors.ACS chemical neuroscience · 2018Review
- Peripherally Administered YFrontiers in pharmacology · 2018Article
- Distinct Penetrance of Obesity-Associated Susceptibility Alleles in the Hungarian General and Roma Populations.Obesity facts · 2017Article
- Posttraumatic stress disorder: A metabolic disorder in disguise?Experimental neurology · 2016Review
- Role of the endocannabinoid system in obesity induced by neuropeptide Y overexpression in noradrenergic neurons.Nutrition & diabetes · 2015Article
- Low-frequency human platelet antigens as triggers for neonatal alloimmune thrombocytopenia.Transfusion · 2014Article
- Genetic variability in energy balance and pancreatic cancer risk in a population-based case-control study in Minnesota.Pancreas · 2014Article
- Neuropeptide Y in the noradrenergic neurons induces the development of cardiometabolic diseases in a transgenic mouse model.Indian journal of endocrinology and metabolism · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
contextNeuropeptide Y (NPY) increases appetite and food intake in animals. Conflicting evidence has been found for the association between polymorphisms of the NPY gene and obesity in humans.
objectiveThe objective of the investigation was to study four single-nucleotide polymorphisms (SNPs) in the NPY gene [rs17149106 (G>T), rs16147 (C>T), rs16139 (T>C), rs5574 (C>T)] with body adiposity.
designThe study design included a candidate gene association study from two cohorts.
participantsTwo thousand seventy-one women from the Nurses' Health Study and 1268 men from the Health Professionals Follow-Up study participated in the study.
main outcome measuresWeight and height were self-reported at baseline and updated every 2 yr to calculate body mass index (BMI).
resultsTwo SNPs (rs17149106 (G>T) and rs16139 (T>C)), with minor allele frequencies of 4%, were associated with elevated risks of obesity (BMI ≥ 30 kg/m(2)) in both cohorts. The pooled adjusted odds ratios [95% confidence interval (CI)] were 1.72 (95% CI 1.20-2.47) and 1.79 (95% CI 1.24-2.60), respectively. Haplotype analyses reflected the associations with the individual SNP. TTCC carriers, with the minor allele of both SNPs, had an increased risk of obesity (odds ratio 1.89; 95% CI 1.29-2.75) compared with those carrying the common haplotype GCTT. Carriers of the rs16139 C allele had greater BMI than noncarriers with a pooled mean difference of +0.58 kg/m(2) (95% CI 0.01-1.15) among women and men. Both rs17149106 and rs16139 were associated with weight gain since adolescence/early adulthood but were not associated with abdominal adiposity as measured by waist circumference and waist to hip ratio.
conclusionsNPY gene variants were significantly associated with weight changes from young adulthood to middle age and with risk of obesity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.