ArticleAmerican journal of physiology. Renal physiology2012
Large BP-dependent and -independent differences in susceptibility to nephropathy after nitric oxide inhibition in Sprague-Dawley rats from two major suppliers.
Article in American journal of physiology. Renal physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 25 citations in OpenAlex.
- Efficacy of Dynamics-based Features for Machine Learning Classification of Renal Hemodynamics.Proceedings of the ... European Signal Processing Conference (EUSIPCO). EUSIPCO (Conference) · 2023Article
- Comparison of the surgical resection and infarct 5/6 nephrectomy rat models of chronic kidney disease.American journal of physiology. Renal physiology · 2022Review
- Salt-Sensitive Hypertension, Renal Injury, and Renal Vasodysfunction Associated With Dahl Salt-Sensitive Rats Are Abolished in Consomic SS.BN1 Rats.Journal of the American Heart Association · 2021Article
- BP Fluctuations and the Real-Time Dynamics of Renal Blood Flow Responses in Conscious Rats.Journal of the American Society of Nephrology : JASN · 2020Article
- Interactions between the complement and endothelin systems in normal pregnancy and following placental ischemia.Molecular immunology · 2019Article
- Hypertensive Kidney Injury and the Progression of Chronic Kidney Disease.Hypertension (Dallas, Tex. : 1979) · 2017Review
- Glomerulosclerosis in the diet-induced obesity model correlates with sensitivity to nitric oxide inhibition but not glomerular hyperfiltration or hypertrophy.American journal of physiology. Renal physiology · 2015Article
- Hemodynamic basis for the limited renal injury in rats with angiotensin II-induced hypertension.American journal of physiology. Renal physiology · 2015Article
- Article
- Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model.Hypertension (Dallas, Tex. : 1979) · 2014Article
- Paraventricular nucleus control of blood pressure in two-kidney, one-clip rats: effects of exercise training and resting blood pressure.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Complement activation is critical for placental ischemia-induced hypertension in the rat.Molecular immunology · 2013Article
- Blood pressure-renal blood flow relationships in conscious angiotensin II- and phenylephrine-infused rats.American journal of physiology. Renal physiology · 2013Article
- Renal microvascular dysfunction, hypertension and CKD progression.Current opinion in nephrology and hypertension · 2013Review
- Resveratrol did not alter blood pressure in rats with nitric oxide synthase-inhibited hypertension.Cardiovascular journal of AfricaArticle
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7 authors at 1 institution in 1 country.
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Abstract
The N(ω)-nitro-l-arginine methyl ester (l-NAME) model is widely employed to investigate the role of nitric oxide (NO) in renal injury. The present studies show that Sprague-Dawley rats from Harlan (H) and Charles River (CR) exhibit strikingly large differences in susceptibility to l-NAME nephropathy. After 4 wk of l-NAME (∼50 mg·kg(-1)·day(-1) in drinking water), H rats (n = 13) exhibited the expected hypertension [average radiotelemetric systolic blood pressure (BP), 180 ± 3 mmHg], proteinuria (136 ± 17 mg/24 h), and glomerular injury (GI) (12 ± 2%). By contrast, CR rats developed less hypertension (142 ± 4), but surprisingly no proteinuria or GI, indicating a lack of glomerular hypertension. Additional studies showed that conscious H, but not CR, rats exhibit dose-dependent renal vasoconstriction after l-NAME. To further investigate these susceptibility differences, l-NAME was given 2 wk after 3/4 normotensive nephrectomy (NX) and comparably impaired renal autoregulation in CR-NX and H-NX rats. CR-NX rats, nevertheless, still failed to develop proteinuria and GI despite moderate hypertension (144 ± 2 mmHg, n = 29). By contrast, despite an 80-90% l-NAME dose reduction and lesser BP increases (169 ± 4 mmHg), H-NX rats (n = 20) developed greater GI (26 ± 3%) compared with intact H rats. Linear regression analysis showed significant (P < 0.01) differences in the slope of the relationship between BP and GI between H-NX (slope 0.56 ± 0.14; r = 0.69; P < 0.008) and CR-NX (slope 0.09 ± 0.06; r = 0.29; P = 0.12) rats. These data indicate that blunted BP responses to l-NAME in the CR rats are associated with BP-independent resistance to nephropathy, possibly mediated by a resistance to the renal (efferent arteriolar) vasoconstrictive effects of NO inhibition.
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