ArticleDevelopment (Cambridge, England)2011
A regulatory program for excretory system regeneration in planarians.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
96 citing papers in PubMed, 159 citations in OpenAlex.
- Flexible use of conserved motifs constrains genome access in cell type evolution.Nature ecology & evolution · 2026Article
- Lack of specificity of planarian progenitor responses to injury in regeneration.bioRxiv : the preprint server for biology · 2026Article
- Multimodal single cell analyses reveal gene networks of planarian stem cell differentiation.Nature communications · 2025Article
- Allometry of cell types in planarians by single-cell transcriptomics.Science advances · 2025Article
- Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians.Heliyon · 2025Review
- Coordinated neuron-glia regeneration through Notch signaling in planarians.PLoS genetics · 2025Article
- Exploring the potential ofCurrent research in toxicology · 2025Article
- Flow Physics Guides Morphology of Ciliated Organs.Nature physics · 2024Article
- Neoblast-like stem cells of Fasciola hepatica.PLoS pathogens · 2024Article
- A transcription factor atlas of stem cell fate in planarians.Cell reports · 2024Article
- LIM-HD transcription factors control axial patterning and specify distinct neuronal and intestinal cell identities in planarians.Open biology · 2023Article
- Fate specification is spatially intermingled across planarian stem cells.Nature communications · 2023Article
- The zebrafish paralog six2b is required for early proximal pronephros morphogenesis.Scientific reports · 2023Article
- The BAF chromatin remodeling complex licenses planarian stem cells access to ectodermal and mesodermal cell fates.BMC biology · 2023Article
- Single-cell atlases of two lophotrochozoan larvae highlight their complex evolutionary histories.Science advances · 2023Article
- Acoel single-cell atlas reveals expression dynamics and heterogeneity of adult pluripotent stem cells.Nature communications · 2023Article
- Review
- Intestine-enriched apolipoprotein b orthologs are required for stem cell progeny differentiation and regeneration in planarians.Nature communications · 2022Article
- The planarian wound epidermis gene equinox is required for blastema formation in regeneration.Nature communications · 2022Article
- Positional Information and Stem Cells Combine to Result in Planarian Regeneration.Cold Spring Harbor perspectives in biology · 2022Review
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Planarians can regenerate any missing body part, requiring mechanisms for the production of organ systems in the adult, including their prominent tubule-based filtration excretory system called protonephridia. Here, we identify a set of genes, Six1/2-2, POU2/3, hunchback, Eya and Sall, that encode transcription regulatory proteins that are required for planarian protonephridia regeneration. During regeneration, planarian stem cells are induced to form a cell population in regeneration blastemas expressing Six1/2-2, POU2/3, Eya, Sall and Osr that is required for excretory system formation. POU2/3 and Six1/2-2 are essential for these precursor cells to form. Eya, Six1/2-2, Sall, Osr and POU2/3-related genes are required for vertebrate kidney development. We determined that planarian and vertebrate excretory cells express homologous proteins involved in reabsorption and waste modification. Furthermore, we identified novel nephridia genes. Our results identify a transcriptional program and cellular mechanisms for the regeneration of an excretory organ and suggest that metazoan excretory systems are regulated by genetic programs that share a common evolutionary origin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.