ArticleNucleic acids research2012
Hepato-specific microRNA-122 facilitates accumulation of newly synthesized miRNA through regulating PRKRA.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Exploring the roles of non-coding RNAs in liver regeneration.Non-coding RNA research · 2024Review
- The MYEOV-MYC association promotes oncogenic miR-17/93-5p expression in pancreatic ductal adenocarcinoma.Cell death & disease · 2021Article
- Review
- Arginine Metabolism and Its Potential in Treatment of Colorectal Cancer.Frontiers in cell and developmental biology · 2021Review
- BCL-w: apoptotic and non-apoptotic role in health and disease.Cell death & disease · 2020Review
- Expression of blood hepatocyte-derived microRNA-122 in canine multicentric lymphoma with hepatic involvement.Veterinary research communications · 2019Article
- Evaluation of hepatocyte-derived microRNA-122 for diagnosis of acute and chronic hepatitis of dogs.Veterinary world · 2018Article
- Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells.The Journal of biological chemistry · 2017Article
- miR-181a-2 downregulates the E3 ubiquitin ligase CUL4A transcript and promotes cell proliferation.Medical oncology (Northwood, London, England) · 2017Article
- Effect of TGF-β/smad signaling pathway blocking on expression profiles of miR-335, miR-150, miR-194, miR-27a, and miR-199a of hepatic stellate cells (HSCs).Gastroenterology and hepatology from bed to bench · 2017Article
- The Hepatoprotective and MicroRNAs Downregulatory Effects of Crocin Following Hepatic Ischemia-Reperfusion Injury in Rats.Oxidative medicine and cellular longevity · 2017Article
- A functional variant at miRNA-122 binding site in IL-1a 3' UTR predicts risk of recurrence in patients with oropharyngeal cancer.Oncotarget · 2016Article
- MicroRNAs in the Evaluation and Potential Treatment of Liver Diseases.Journal of clinical medicine · 2016Review
- MiR-122 targets VEGFC in bladder cancer to inhibit tumor growth and angiogenesis.American journal of translational research · 2016Article
- A functional variant at miRNA-122 binding site in IL-1α 3' UTR predicts risk and HPV-positive tumours of oropharyngeal cancer.European journal of cancer (Oxford, England : 1990) · 2015Article
- MicroRNA-122 Inhibits the Production of Inflammatory Cytokines by Targeting the PKR Activator PACT in Human Hepatic Stellate Cells.PloS one · 2015Article
- Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAs.Genome biology · 2014Article
- MicroRNAs in the onset and development of cardiovascular disease.Clinical science (London, England : 1979) · 2014Review
- MiR-10a* up-regulates coxsackievirus B3 biosynthesis by targeting the 3D-coding sequence.Nucleic acids research · 2013Article
- The hunting of targets: challenge in miRNA research.Leukemia · 2013Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
microRNAs (miRNAs) are a versatile class of non-coding RNAs involved in regulation of various biological processes. miRNA-122 (miR-122) is specifically and abundantly expressed in human liver. In this study, we employed 3'-end biotinylated synthetic miR-122 to identify its targets based on affinity purification. Quantitative RT-PCR analysis of the affinity purified RNAs demonstrated a specific enrichment of several known miR-122 targets such as CAT-1 (also called SLC7A1), ADAM17 and BCL-w. Using microarray analysis of affinity purified RNAs, we also discovered many candidate target genes of miR-122. Among these candidates, we confirmed that protein kinase, interferon-inducible double-stranded RNA-dependent activator (PRKRA), a Dicer-interacting protein, is a direct target gene of miR-122. miRNA quantitative-RT-PCR results indicated that miR-122 and small interfering RNA against PRKRA may facilitate the accumulation of newly synthesized miRNAs but did not detectably affect endogenous miRNAs levels. Our findings will lead to further understanding of multiple functions of this hepato-specific miRNA. We conclude that miR-122 could repress PRKRA expression and facilitate accumulation of newly synthesized miRNAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.