ArticleThe Journal of biological chemistry2011
Patterns of histone H3 lysine 27 monomethylation and erythroid cell type-specific gene expression.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Epigenetic alterations in Myeloid Malignancies.Advances in experimental medicine and biology · 2026Review
- A narrative review of epigenetic marker in H3K27ac and its emerging potential as a therapeutic target in cancer.Epigenomics · 2025Review
- Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications.Nature structural & molecular biology · 2025Article
- Article
- Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications.bioRxiv : the preprint server for biology · 2024Article
- miR-155 Accelerates the Growth of Human Liver Cancer Cells by Activating CDK2 via Targeting H3F3A.Molecular therapy oncolytics · 2020Article
- Faint gray bands in Drosophila melanogaster polytene chromosomes are formed by coding sequences of housekeeping genes.Chromosoma · 2020Article
- Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus.Stem cell reports · 2019Article
- Epigenomic Reordering Induced by Polycomb Loss Drives Oncogenesis but Leads to Therapeutic Vulnerabilities in Malignant Peripheral Nerve Sheath Tumors.Cancer research · 2019Article
- H3K27me1 is essential for MMP-9-dependent H3N-terminal tail proteolysis during osteoclastogenesis.Epigenetics & chromatin · 2018Article
- Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.Nature structural & molecular biology · 2018Article
- Article
- Genome Silencing and Elimination: Insights from a "Selfish" B Chromosome.Frontiers in genetics · 2017Review
- Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells.Cell reports · 2016Article
- Lysine demethylase 2A promotes stemness and angiogenesis of breast cancer by upregulating Jagged1.Oncotarget · 2016Article
- CTCF and CohesinSA-1 Mark Active Promoters and Boundaries of Repressive Chromatin Domains in Primary Human Erythroid Cells.PloS one · 2016Article
- Chromatin-bound RNA and the neurobiology of psychiatric disease.Neuroscience · 2014Review
- Glial progenitors as targets for transformation in glioma.Advances in cancer research · 2014Review
- A lesson learned from the H3.3K27M mutation found in pediatric glioma: a new approach to the study of the function of histone modifications in vivo?Cell cycle (Georgetown, Tex.) · 2013Article
- Identification of biologically relevant enhancers in human erythroid cells.The Journal of biological chemistry · 2013Article
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5 authors.
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Abstract
Post-translational histone modifications, acting alone or in a context-dependent manner, influence numerous cellular processes via their regulation of gene expression. Monomethylation of histone H3 lysine 27 (K27me1) is a poorly understood histone modification. Some reports describe depletion of K27Me1 at promoters and transcription start sites (TSS), implying its depletion at TSS is necessary for active transcription, while others have associated enrichment of H3K27me1 at TSS with increased levels of mRNA expression. Tissue- and gene-specific patterns of H3K27me1 enrichment and their correlation with gene expression were determined via chromatin immunoprecipitation on chip microarray (ChIP-chip) and human mRNA expression array analyses. Results from erythroid cells were compared with those in neural and muscle cells. H3K27me1 enrichment varied depending on levels of cell-type specific gene expression, with highest enrichment over transcriptionally active genes. Over individual genes, the highest levels of H3K27me1 enrichment were found over the gene bodies of highly expressed genes. In contrast to H3K4me3, which was highly enriched at the TSS of actively transcribing genes, H3K27me1 was selectively depleted at the TSS of actively transcribed genes. There was markedly decreased to no H3K27me1 enrichment in genes with low expression. At some locations, H3K27 monomethylation was also found to be associated with chromatin signatures of gene enhancers.
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