ArticleVeterinary research2011
Genome of Mycoplasma haemofelis, unraveling its strategies for survival and persistence.
Article in Veterinary research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Unveiling the diversity of hemoplasmas (hemotropic Mycoplasma spp.) in Brazilian wildlife: two decades of molecular discoveries - a scoping review.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2026Article
- Hidden hemoplasma species within the "Candidatus Mycoplasma haemominutum" lineage in Thai cats revealed by analyses of two independent genetic markers.Parasites & vectors · 2025Article
- The gut microbiome of farmed Arctic char (FEMS microbes · 2024Article
- Clinical, haematological and pathomorphological findings in Mycoplasma suis infected pigs.BMC veterinary research · 2021Article
- Non-targeted metabolomics reveals diagnostic biomarker in the tongue coating of patients with chronic gastritis.Journal of pharmaceutical and biomedical analysis · 2019Article
- Persistence of Functional Protein Domains in Mycoplasma Species and their Role in Host Specificity and Synthetic Minimal Life.Frontiers in cellular and infection microbiology · 2017Article
- Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells.Analytical and bioanalytical chemistry · 2016Article
- Ureaplasma diversum Genome Provides New Insights about the Interaction of the Surface Molecules of This Bacterium with the Host.PloS one · 2016Article
- Comparative genome analysis of Mycoplasma pneumoniae.BMC genomics · 2015Article
- Microscopy and genomic analysis of Mycoplasma parvum strain Indiana.Veterinary research · 2014Article
- Complete Genome Sequence of Mycoplasma ovis Strain Michigan, a Hemoplasma of Sheep with Two Distinct 16S rRNA Genes.Genome announcements · 2014Article
- Article
- Genome Sequence of Mycoplasma parvum (Formerly Eperythrozoon parvum), a Diminutive Hemoplasma of the Pig.Genome announcements · 2013Article
- Protection from reinfection in "Candidatus Mycoplasma turicensis"-infected cats and characterization of the immune response.Veterinary research · 2012Article
- Genome sequence of "Candidatus Mycoplasma haemolamae" strain purdue, a red blood cell pathogen of alpacas (Vicugna pacos) and llamas (Lama glama).Journal of bacteriology · 2012Article
- Complete genome sequence of Mycoplasma wenyonii strain Massachusetts.Journal of bacteriology · 2012Article
- Mycoplasma haemocanis--the canine hemoplasma and its feline counterpart in the genomic era.Veterinary research · 2012Article
- Emergence of atypical Mycoplasma agalactiae strains harboring a new prophage and associated with an alpine wild ungulate mortality episode.Applied and environmental microbiology · 2012Article
- Complete genome sequence of Mycoplasma haemocanis strain Illinois.Journal of bacteriology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycoplasma haemofelis is a mycoplasmal pathogen (hemoplasma) that attaches to the host's erythrocytes. Distributed worldwide, it has a significant impact on the health of cats causing acute disease and, despite treatment, establishing chronic infection. It might also have a role as a zoonotic agent, especially in immunocompromised patients. Whole genome sequencing and analyses of M. haemofelis strain Ohio2 was undertaken as a step toward understanding its survival and persistence. Metabolic pathways are reduced, relying on the host to supply many of the nutrients and metabolites needed for survival. M. haemofelis must import glucose for ATP generation and ribose derivates for RNA/DNA synthesis. Hypoxanthine, adenine, guanine, uracil and CMP are scavenged from the environment to support purine and pyrimidine synthesis. In addition, nicotinamide, amino acids and any vitamins needed for growth, must be acquired from its environment. The core proteome of M. haemofelis contains an abundance of paralogous gene families, corresponding to 70.6% of all the CDSs. This "paralog pool" is a rich source of different antigenic epitopes that can be varied to elude the host's immune system and establish chronic infection. M. haemofelis also appears to be capable of phase variation, which is particularly relevant to the cyclic bacteremia and persistence, characteristics of the infection in the cat. The data generated herein should be of great use for understanding the mechanisms of M. haemofelis infection. Further, it will provide new insights into its pathogenicity and clues needed to formulate media to support the in vitro cultivation of M. haemofelis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.