ArticleMolecular pain2011
Migraine attacks the Basal Ganglia.
Article in Molecular pain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
What it found
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The trial behind it
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Who cites it
84 citing papers in PubMed, 159 citations in OpenAlex.
- High-definition tDCS over primary motor cortex modulates brain signal variability and functional connectivity in episodic migraine.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Trial
- Increased iron deposition in nucleus accumbens associated with disease progression and chronicity in migraine.BMC medicine · 2023Trial
- Dopaminergic Dysregulation in Migraine: From Hypothalamic A11 Dysfunction to a Systemic Biobehavioral Phenotype.International journal of molecular sciences · 2026Review
- Semantic Content of Visual Consequent Stimuli Modulates Audiovisual Learning in Migraine.Brain and behavior · 2026Article
- Expanding the Spectrum of Central Sensitivity Syndrome: Integrating Otologic Migraine as Otologic Central Sensitivity Syndrome.Brain sciences · 2026Review
- Exploring Heterogeneity in Vestibular Migraine Using Individualized Differential Structural Covariance Network Analysis.CNS neuroscience & therapeutics · 2025Article
- Mechanistic intersections between migraine and major depressive disorder.The journal of headache and pain · 2025Review
- Pathophysiological changes in incentive processing in episodic migraine: a preliminary event-related potential study.Social cognitive and affective neuroscience · 2025Article
- Offset analgesia as a marker of dysfunctional pain modulation in episodic and chronic migraine.The journal of headache and pain · 2025Article
- Assessing the Modulatory Effects of tDCS and Acupuncture on Cerebral Blood Flow in Chronic Low Back Pain Using Arterial Spin Labeling Perfusion Imaging.Brain sciences · 2025Article
- Brain structures as potential mediators of the causal effect of COVID 19 on migraine risk.Scientific reports · 2024Article
- Resting-state brain activity as a biomarker of chronic pain impairment and a mediator of its association with pain resilience.Human brain mapping · 2024Article
- Models of Trigeminal Activation: Is There an Animal Model of Migraine?Brain sciences · 2024Review
- Suboptimal multisensory processing in pediatric migraine without aura: a comparative, cross-sectional study.Scientific reports · 2023Article
- Trigeminocervical pain sensitivity during the migraine cycle depends on headache frequency.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Observational
- Migraine: Advances in the Pathogenesis and Treatment.Neurology international · 2023Review
- Galcanezumab effects on incidence of headache after occurrence of triggers, premonitory symptoms, and aura in responders, non-responders, super-responders, and super non-responders.The journal of headache and pain · 2023Observational
- Altered functional connectivity of the right caudate nucleus in chronic migraine: a resting-state fMRI study.The journal of headache and pain · 2022Article
- Article
- Migraine and peripheral pain models show differential alterations in neuronal complexity.Headache · 2022Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundWith time, episodes of migraine headache afflict patients with increased frequency, longer duration and more intense pain. While episodic migraine may be defined as 1-14 attacks per month, there are no clear-cut phases defined, and those patients with low frequency may progress to high frequency episodic migraine and the latter may progress into chronic daily headache (> 15 attacks per month). The pathophysiology of this progression is completely unknown. Attempting to unravel this phenomenon, we used high field (human) brain imaging to compare functional responses, functional connectivity and brain morphology in patients whose migraine episodes did not progress (LF) to a matched (gender, age, age of onset and type of medication) group of patients whose migraine episodes progressed (HF).
resultsIn comparison to LF patients, responses to pain in HF patients were significantly lower in the caudate, putamen and pallidum. Paradoxically, associated with these lower responses in HF patients, gray matter volume of the right and left caudate nuclei were significantly larger than in the LF patients. Functional connectivity analysis revealed additional differences between the two groups in regard to response to pain.
conclusionsSupported by current understanding of basal ganglia role in pain processing, the findings suggest a significant role of the basal ganglia in the pathophysiology of the episodic migraine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.