Evidence map›Paper›PMID 21936774›Full record

ReviewBiochemical Society transactions2011

Myosin motor proteins are involved in the final stages of the secretory pathways.

Lisa M Bond, Hemma Brandstaetter, James R Sellers, John Kendrick-Jones, Folma Buss

Abstract readReview
In one paragraph

Review in Biochemical Society transactions, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Frontiers in endocrinology · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Myosin-Driven Intracellular Transport.Cold Spring Harbor perspectives in biology · 2018
    Review
  10. How Myosin Generates Force on Actin Filaments.Trends in biochemical sciences · 2016
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Characterization of CFTR High Expresser cells in the intestine.American journal of physiology. Gastrointestinal and liver physiology · 2013
    Article
  18. Multiple roles for the actin cytoskeleton during regulated exocytosis.Cellular and molecular life sciences : CMLS · 2013
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Lisa M BondCambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.
Hemma Brandstaetter
James R Sellers
John Kendrick-Jones
Folma Buss
Wellcome/MRC Cambridge Stem Cell Institute · GBMRC Laboratory of Molecular Biology · GBNational Heart Lung and Blood Institute · US

Funding

Function of Myosin VIZIAHL006048 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SELLERS, JAMES · 2010 to 2012
$599k
Medical Research Council MC_U105184323Wellcome Trust 086743
6 · The paper itself

Abstract

In eukaryotes, the final steps in both the regulated and constitutive secretory pathways can be divided into four distinct stages: (i) the 'approach' of secretory vesicles/granules to the PM (plasma membrane), (ii) the 'docking' of these vesicles/granules at the membrane itself, (iii) the 'priming' of the secretory vesicles/granules for the fusion process, and, finally, (iv) the 'fusion' of vesicular/granular membranes with the PM to permit content release from the cell. Recent work indicates that non-muscle myosin II and the unconventional myosin motor proteins in classes 1c/1e, Va and VI are specifically involved in these final stages of secretion. In the present review, we examine the roles of these myosins in these stages of the secretory pathway and the implications of their roles for an enhanced understanding of secretion in general.

Indexed as

Cell MembraneExocytosisHumansMembrane FusionMolecular Motor ProteinsMyosinsNonmuscle Myosin Type IIAProtein IsoformsSecretory PathwaySecretory VesiclesMolecular Motor ProteinsMyosinsNonmuscle Myosin Type IIAProtein Isoforms

Identifiers

PMID21936774
PMCPMC3403808
OpenAlexW2052440302

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.