ArticleThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry2013
Serotonin 1B receptor imaging in pathological gambling.
Article in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Shared gray matter alterations in individuals with diverse behavioral addictions: A voxel-wise meta-analysis.Journal of behavioral addictions · 2020Pooled it
- Neurobiological considerations in understanding behavioral treatments for pathological gambling.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2013Trial
- Similarities and Differences in Neurobiology.Advances in experimental medicine and biology · 2025Review
- Loss, gain and choice difficulty in gambling patients: Neural and behavioural processes.Addiction biology · 2024Article
- Neurotransmitters crosstalk and regulation in the reward circuit of subjects with behavioral addiction.Frontiers in psychiatry · 2024Review
- Serotonergic and dopaminergic control of impulsivity in gambling disorder.Addiction biology · 2023Article
- Chinese version of exercise dependence scale-revised: psychometric analysis and exploration of risk factors.Frontiers in psychology · 2023Article
- Neuroimaging of reward mechanisms in Gambling disorder: an integrative review.Molecular psychiatry · 2019Review
- The 5-HTPsychopharmacology · 2018Review
- Mirtazapine and ketanserin alter preference for gambling-like schedules of reinforcement in rats.Progress in neuro-psychopharmacology & biological psychiatry · 2017Article
- Gambling disorder: an integrative review of animal and human studies.Annals of the New York Academy of Sciences · 2017Review
- Peripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making.The international journal of neuropsychopharmacology · 2017Article
- Serotonin receptors in depression: from A to B.F1000Research · 2017Review
- OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding.Journal of affective disorders · 2016Article
- Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity.Neuron · 2015Article
- Test-retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943.European journal of nuclear medicine and molecular imaging · 2015Article
- Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans.Biological psychiatry · 2014Article
- The neural bases of cognitive processes in gambling disorder.Trends in cognitive sciences · 2014Review
- A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques.Translational psychiatry · 2014Article
- A targeted review of the neurobiology and genetics of behavioural addictions: an emerging area of research.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2013Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Abstract Objectives. Although serotonergic mechanisms have been implicated in pathological gambling (PG), no ligand-based imaging studies have assessed serotonin receptors in individuals with PG. Given its role in substance addictions and its abundance in brain regions implicated in PG, we evaluated serotonin 1B receptors (5-HT1BRs) in PG. Methods. Ten medication-free subjects with PG (mean ± SD age = 36.3 ± 9.4 years, nine men) and ten control comparison (CC) subjects (mean ± SD age = 35.8 ± 9.9 years, nine men) underwent [(11)C]P943 positron emission scanning on a high resolution research tomograph. Results. 5-HT1BR BPND values were similar in PG and CC subjects (P > 0.1). Among PG subjects, scores on the South Oaks Gambling Screen (SOGS) correlated positively with 5-HT1BR BPND values in the ventral striatum (r = 0.66; P = 0.04), putamen (r = 0.67; P = 0.03) and anterior cingulate cortex (r = 0.73; P = 0.02). Conclusions. These findings provide the first evidence that PG severity in humans is linked to increased levels of 5-HT1BRs in regions previously implicated in functional neuroimaging studies of PG. These findings indicate a potential role for serotonergic function in the ventral striatum and anterior cingulate cortex contributing to problem gambling severity and warrant further studies to investigate whether numbers of available 5-HT1BRs might represent a vulnerability factor for PG or develop in relationship to problem gambling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.