ArticleProtein science : a publication of the Protein Society2011
Comparative structural and functional characterization of putative protein effectors belonging to the PcF toxin family from Phytophthora spp.
Article in Protein science : a publication of the Protein Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 18 citations in OpenAlex.
- The devastating oomycete phytopathogen Phytophthora cactorum: Insights into its biology and molecular features.Molecular plant pathology · 2023Review
- Time-Course Transcriptome Profiling Reveals Differential Resistance Responses of Tomato to a Phytotoxic Effector of the Pathogenic OomycetePlants (Basel, Switzerland) · 2023Article
- Transcription profiling and identification of infection-related genes in Phytophthora cactorum.Molecular genetics and genomics : MGG · 2018Article
- Phytophthora cinnamomi.Molecular plant pathology · 2018Article
- Bioinformatic characterisation of the effector repertoire of the strawberry pathogen Phytophthora cactorum.PloS one · 2018Article
- SCR96, a small cysteine-rich secretory protein of Phytophthora cactorum, can trigger cell death in the Solanaceae and is important for pathogenicity and oxidative stress tolerance.Molecular plant pathology · 2016Article
- Molecular modeling of NK-CT1, from Indian monocellate cobra (Naja kaouthia) and its docking interaction with human DNA topoisomerase II alpha.Bioinformation · 2016Article
- Transcriptomic analysis of the phytopathogenic oomycete Phytophthora cactorum provides insights into infection-related effectors.BMC genomics · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
The PcF Toxin Family (Pfam 09461) includes the characterized phytotoxic protein PcF from Phytophthora cactorum, as well as several predicted protein effectors from other Phytophthora species recently identified by comparative genomics. Here we provide first evidence that such 'putatives', recombinantly expressed in bacteria and purified to homogeneity, similarly to PcF, can trigger defense-related responses on tomato, that is leaf withering and phenylalanine ammonia lyase induction, although with various degrees of effectiveness. In addition, structural prediction by computer-aided homology modeling and subsequent structural/functional comparison after rational engineering of the disulfide-structured protein fold by site-directed mutagenesis, highlighted the surface-exposed conserved amino acid stretch SK(E/C)C as a possible structural determinant responsible for the differential phytotoxicity within this family of cognate protein effectors.
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