ArticlePloS one2011
A phylometagenomic exploration of oceanic alphaproteobacteria reveals mitochondrial relatives unrelated to the SAR11 clade.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed.
- Role of Mitochondrial Dysfunctions in Neurodegenerative Disorders: Advances in Mitochondrial Biology.Molecular neurobiology · 2025Review
- Origin and evolution of mitochondrial inner membrane composition.Journal of cell science · 2025Review
- Comparative structure and evolution of the organellar genomes of Padina usoehtunii (Dictyotales) with the brown algal crown radiation clade.BMC genomics · 2024Article
- "Superwobbling" and tRNA-34 Wobble and tRNA-37 Anticodon Loop Modifications in Evolution and Devolution of the Genetic Code.Life (Basel, Switzerland) · 2022Review
- The Mysterious Multitude: Structural Perspective on the Accessory Subunits of Respiratory Complex I.Frontiers in molecular biosciences · 2021Review
- Airway host-microbiome interactions in chronic obstructive pulmonary disease.Respiratory research · 2019Article
- An updated phylogeny of theeLife · 2019Article
- Article
- Archaea and the origin of eukaryotes.Nature reviews. Microbiology · 2017Review
- Breath-giving cooperation: critical review of origin of mitochondria hypotheses : Major unanswered questions point to the importance of early ecology.Biology direct · 2017Review
- Insights into origin and evolution of α-proteobacterial gene transfer agents.Virus evolution · 2017Article
- Single-cell genomics of a rare environmental alphaproteobacterium provides unique insights into Rickettsiaceae evolution.The ISME journal · 2015Article
- Molecular evolution of cytochrome bd oxidases across proteobacterial genomes.Genome biology and evolution · 2015Article
- An integrated phylogenomic approach toward pinpointing the origin of mitochondria.Scientific reports · 2015Article
- Genomics and Evolution in Traditional Medicinal Plants: Road to a Healthier Life.Evolutionary bioinformatics online · 2015Review
- Eukaryotic origins: How and when was the mitochondrion acquired?Cold Spring Harbor perspectives in biology · 2014Review
- Phylogenomic test of the hypotheses for the evolutionary origin of eukaryotes.Molecular biology and evolution · 2014Article
- The pre-endosymbiont hypothesis: a new perspective on the origin and evolution of mitochondria.Cold Spring Harbor perspectives in biology · 2014Review
- tRNA signatures reveal a polyphyletic origin of SAR11 strains among alphaproteobacteria.PLoS computational biology · 2014Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccording to the endosymbiont hypothesis, the mitochondrial system for aerobic respiration was derived from an ancestral Alphaproteobacterium. Phylogenetic studies indicate that the mitochondrial ancestor is most closely related to the Rickettsiales. Recently, it was suggested that Candidatus Pelagibacter ubique, a member of the SAR11 clade that is highly abundant in the oceans, is a sister taxon to the mitochondrial-Rickettsiales clade. The availability of ocean metagenome data substantially increases the sampling of Alphaproteobacteria inhabiting the oxygen-containing waters of the oceans that likely resemble the originating environment of mitochondria. METHODOLOGY/PRINCIPAL
findingsWe present a phylogenetic study of the origin of mitochondria that incorporates metagenome data from the Global Ocean Sampling (GOS) expedition. We identify mitochondrially related sequences in the GOS dataset that represent a rare group of Alphaproteobacteria, designated OMAC (Oceanic Mitochondria Affiliated Clade) as the closest free-living relatives to mitochondria in the oceans. In addition, our analyses reject the hypothesis that the mitochondrial system for aerobic respiration is affiliated with that of the SAR11 clade. CONCLUSIONS/SIGNIFICANCE: Our results allude to the existence of an alphaproteobacterial clade in the oxygen-rich surface waters of the oceans that represents the closest free-living relative to mitochondria identified thus far. In addition, our findings underscore the importance of expanding the taxonomic diversity in phylogenetic analyses beyond that represented by cultivated bacteria to study the origin of mitochondria.
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