ArticlePloS one2011
Receptor for activated protein kinase C: requirement for efficient microRNA function and reduced expression in hepatocellular carcinoma.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- A Duality of Function: An Integrative Model of RACK1 as a Switch Between Translational and Signaling Hubs.International journal of molecular sciences · 2025Review
- The Roles of microRNA miR-185 in Digestive Tract Cancers.Non-coding RNA · 2022Review
- Identification of Pri-miRNA Stem-Loop Interacting Proteins in Plants Using a Modified Version of the Csy4 CRISPR Endonuclease.International journal of molecular sciences · 2022Article
- A new KSRP-binding compound suppresses distant metastasis of colorectal cancer by targeting the oncogenic KITENIN complex.Molecular cancer · 2021Article
- miR393s regulate salt stress response pathway in Arabidopsis thaliana through scaffold protein RACK1A mediated ABA signaling pathways.Plant signaling & behavior · 2019Article
- Opposing roles of microRNA Argonautes during Caenorhabditis elegans aging.PLoS genetics · 2018Article
- Definition of a RACK1 Interaction Network inG3 (Bethesda, Md.) · 2017Article
- The Receptor for Activated C Kinase in Plant Signaling: Tale of a Promiscuous Little Molecule.Frontiers in plant science · 2015Review
- Article
- Overexpressed RACK1 is positively correlated with malignant degree of human colorectal carcinoma.Molecular biology reports · 2014Article
- Review
- New insights on the role of epigenetic alterations in hepatocellular carcinoma.Journal of hepatocellular carcinoma · 2014Review
- RACK1 and the microRNA pathway: is it déjà-vu all over again?Plant signaling & behavior · 2014Review
- RACK-1 regulates let-7 microRNA expression and terminal cell differentiation in Caenorhabditis elegans.Cell cycle (Georgetown, Tex.) · 2014Article
- MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression.Hepatology (Baltimore, Md.) · 2013Article
- Differential association of microRNAs with polysomes reflects distinct strengths of interactions with their mRNA targets.RNA (New York, N.Y.) · 2012Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are important regulators of gene expression that control physiological and pathological processes. A global reduction in miRNA abundance and function is a general trait of human cancers, playing a causal role in the transformed phenotype. Here, we sought to newly identify genes involved in the regulation of miRNA function by performing a genetic screen using reporter constructs that measure miRNA function and retrovirus-based random gene disruption. Of the six genes identified, RACK1, which encodes "receptor for activated protein kinase C" (RACK1), was confirmed to be necessary for full miRNA function. RACK1 binds to KH-type splicing regulatory protein (KSRP), a member of the Dicer complex, and is required for the recruitment of mature miRNAs to the RNA-induced silencing complex (RISC). In addition, RACK1 expression was frequently found to be reduced in hepatocellular carcinoma. These findings suggest the involvement of RACK1 in miRNA function and indicate that reduced miRNA function, due to decreased expression of RACK1, may have pathologically relevant roles in liver cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.