ArticlePloS one2011
Impaired thymic export and apoptosis contribute to regulatory T-cell defects in patients with chronic heart failure.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Reduced circulating regulatory T cells in primary Sjögren's syndrome: the contribution of enhanced apoptosis and impaired survival.Frontiers in immunology · 2025Article
- The Immune System, An Arrow into the Heart. Principles of Cardioimmunology, An Emerging Branch in Medicine.Current vascular pharmacology · 2025Review
- Investigating the causal relationship between immune cell and Alzheimer's disease: a mendelian randomization analysis.BMC neurology · 2024Article
- Xin-Li formula attenuates heart failure induced by a combination of hyperlipidemia and myocardial infarction in rats via Treg immunomodulation and NLRP3 inflammasome inhibition.Journal of traditional and complementary medicine · 2023Article
- Naïve-memory regulatory T cells ratio is a prognostic biomarker for patients with acute ischemic stroke.Frontiers in aging neuroscience · 2023Article
- Article
- Soluble fibrinogen‑like protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function.Molecular medicine reports · 2021Article
- Regulatory T Cells in Chronic Heart Failure.Frontiers in immunology · 2021Review
- Inflammatory Cytokines, Immune Cells, and Organ Interactions in Heart Failure.Frontiers in physiology · 2021Review
- Cysteinyl cathepsins in cardiovascular diseases.Biochimica et biophysica acta. Proteins and proteomics · 2020Review
- T-cell recruitment to the heart: friendly guests or unwelcome visitors?American journal of physiology. Heart and circulatory physiology · 2019Review
- Lymphocytic subsets play distinct roles in heart diseases.Theranostics · 2019Review
- Expression of pericardial fluid T-cells and related inflammatory cytokines in patients with chronic heart failure.Experimental and therapeutic medicine · 2017Article
- Human Tregs Made Antigen Specific by Gene Modification: The Power to Treat Autoimmunity and Antidrug Antibodies with Precision.Frontiers in immunology · 2017Review
- Thymic hyperplasia after chemotherapy in adults with mature B cell lymphoma and its influence on thymic output and CD4(+) T cells repopulation.Oncoimmunology · 2016Article
- Regulatory T cells in cardiovascular diseases.Nature reviews. Cardiology · 2016Review
- Impaired circulating CD4+ LAP+ regulatory T cells in patients with acute coronary syndrome and its mechanistic study.PloS one · 2014Article
- Infection, Oxidative Stress, and Changes in Circulating Regulatory T Cells of Heart Failure Patients Supported by Continuous-Flow Ventricular Assist Devices.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
Corrections and comments
- Erratum issuedYan, Xing-Xing [corrected to Yan, Xin-Xin]
Authors and funding
25 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveAnimal studies suggest that regulatory T (T(reg)) cells play a beneficial role in ventricular remodeling and our previous data have demonstrated defects of T(reg) cells in patients with chronic heart failure (CHF). However, the mechanisms behind T(reg-)cell defects remained unknown. We here sought to elucidate the mechanism of T(reg-)cell defects in CHF patients. METHODS AND
resultsWe performed flow cytometry analysis and demonstrated reduced numbers of peripheral blood CD4(+)CD25(+)FOXP3(+)CD45RO(-)CD45RA(+) naïve T(reg) (nT(reg)) cells and CD4(+)CD25(+)FOXP3(+)CD45RO(+)CD45RA(-) memory T(reg) (mT(reg)) cells in CHF patients as compared with non-CHF controls. Moreover, the nT(reg)/mT(reg) ratio (p<0.01), CD4(+)CD25(+)FOXP3(+)CD45RO(-) CD45RA(+)CD31(+) recent thymic emigrant T(reg) cell (RTE-T(reg)) frequency (p<0.01), and T-cell receptor excision circle levels in T(reg) cells (p<0.01) were lower in CHF patients than in non-CHF controls. Combined annexin-V and 7-AAD staining showed that peripheral T(reg) cells from CHF patients exhibited increased spontaneous apoptosis and were more prone to interleukin (IL)-2 deprivation- and CD95 ligand-mediated apoptosis than those from non-CHF individuals. Furthermore, analyses by both flow cytometry and real-time polymerase chain reaction showed that T(reg)-cell frequency in the mediastinal lymph nodes or Foxp3 expression in hearts of CHF patients was no higher than that of the non-CHF controls.
conclusionOur data suggested that the T(reg)-cell defects of CHF patients were likely caused by decreased thymic output of nascent T(reg) cells and increased susceptibility to apoptosis in the periphery.
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