ArticlePLoS computational biology2011
Retracing micro-epidemics of Chagas disease using epicenter regression.
Article in PLoS computational biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- An immune system for the city: A cluster-randomized trial of a new paradigm for surveillance and control of disease vectors.PLoS neglected tropical diseases · 2026Trial
- Barriers to surveillance and control of re-emergence of the Chagas disease vector Triatoma infestans in Arequipa, Peru.PLoS neglected tropical diseases · 2025Article
- Over-dispersed Trypanosoma cruzi parasite load in sylvatic and domestic mammals and humans from northeastern Argentina.Parasites & vectors · 2022Article
- Human Trypanosoma cruzi infection is driven by eco-social interactions in rural communities of the Argentine Chaco.PLoS neglected tropical diseases · 2019Article
- Article
- Integrating evidence, models and maps to enhance Chagas disease vector surveillance.PLoS neglected tropical diseases · 2018Article
- Article
- To spray or not to spray? Understanding participation in an indoor residual spray campaign in Arequipa, Peru.Global public health · 2018Article
- Increasing participation in a vector control campaign: a cluster randomised controlled evaluation of behavioural economic interventions in Peru.BMJ global health · 2018Article
- Modelling historical changes in the force-of-infection of Chagas disease to inform control and elimination programmes: application in Colombia.BMJ global health · 2017Article
- The ecological foundations of transmission potential and vector-borne disease in urban landscapes.Functional ecology · 2015Article
- The potential of canine sentinels for reemerging Trypanosoma cruzi transmission.Preventive veterinary medicine · 2015Article
- Prevalence and Transmission of Trypanosoma cruzi in People of Rural Communities of the High Jungle of Northern Peru.PLoS neglected tropical diseases · 2015Article
- Bed bugs (Cimex lectularius) as vectors of Trypanosoma cruzi.The American journal of tropical medicine and hygiene · 2015Article
- Urbanization, land tenure security and vector-borne Chagas disease.Proceedings. Biological sciences · 2014Article
- Characterization of guinea pig antibody responses to salivary proteins of Triatoma infestans for the development of a triatomine exposure marker.PLoS neglected tropical diseases · 2014Article
- A country bug in the city: urban infestation by the Chagas disease vector Triatoma infestans in Arequipa, Peru.International journal of health geographics · 2013Article
- Population structure of the Chagas disease vector, Triatoma infestans, at the urban-rural interface.Molecular ecology · 2013Article
- The effects of city streets on an urban disease vector.PLoS computational biology · 2013Article
- A field trial of alternative targeted screening strategies for Chagas disease in Arequipa, Peru.PLoS neglected tropical diseases · 2012Article
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Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
Abstract
Vector-borne transmission of Chagas disease has become an urban problem in the city of Arequipa, Peru, yet the debilitating symptoms that can occur in the chronic stage of the disease are rarely seen in hospitals in the city. The lack of obvious clinical disease in Arequipa has led to speculation that the local strain of the etiologic agent, Trypanosoma cruzi, has low chronic pathogenicity. The long asymptomatic period of Chagas disease leads us to an alternative hypothesis for the absence of clinical cases in Arequipa: transmission in the city may be so recent that most infected individuals have yet to progress to late stage disease. Here we describe a new method, epicenter regression, that allows us to infer the spatial and temporal history of disease transmission from a snapshot of a population's infection status. We show that in a community of Arequipa, transmission of T. cruzi by the insect vector Triatoma infestans occurred as a series of focal micro-epidemics, the oldest of which began only around 20 years ago. These micro-epidemics infected nearly 5% of the community before transmission of the parasite was disrupted through insecticide application in 2004. Most extant human infections in our study community arose over a brief period of time immediately prior to vector control. According to our findings, the symptoms of chronic Chagas disease are expected to be absent, even if the strain is pathogenic in the chronic phase of disease, given the long asymptomatic period of the disease and short history of intense transmission. Traducción al español disponible en Alternative Language Text S1/A Spanish translation of this article is available in Alternative Language Text S1.
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