ArticleClinicoEconomics and outcomes research : CEOR2011
Adherence to antihypertensive medications and health outcomes among newly treated hypertensive patients.
Article in ClinicoEconomics and outcomes research : CEOR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- The link between adherence to antihypertensive medications and mortality rates in patients with hypertension: a systematic review and meta-analysis of cohort studies.BMC cardiovascular disorders · 2025Pooled it
- Impacts of medication non-adherence to major modifiable stroke-related diseases on stroke prevention and mortality: a meta-analysis.Journal of neurology · 2023Pooled it
- Adherence to Antihypertensive Medications and Stroke Risk: A Dose-Response Meta-Analysis.Journal of the American Heart Association · 2017Pooled it
- A Motivational Interviewing Intervention to Improve Adherence to ACEIs/ARBs among Nonadherent Older Adults with Comorbid Hypertension and Diabetes.Drugs & aging · 2023Trial
- The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care: a randomised clinical controlled trial.Scientific reports · 2021Trial
- A Highly Tailored Text and Voice Messaging Intervention to Improve Medication Adherence in Patients With Either or Both Hypertension and Type 2 Diabetes in a UK Primary Care Setting: Feasibility Randomized Controlled Trial of Clinical Effectiveness.Journal of medical Internet research · 2020Trial
- Adherence and Healthcare Costs Associated with Single-vs Free-Pill Combination of Perindopril-Based Antihypertensive Medications: An 11-Year Follow-Up, Real-World Evidence.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026Article
- Sex stratified analysis of patients with resistant hypertension from the Global SYMPLICITY Registry of renal denervation.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Adherence, Persistence, and Blood Pressure Control in Hypertensive Patients: A Cross-Sectional Study in Mureș County, Romania.Medical sciences (Basel, Switzerland) · 2025Article
- Factors influencing self-report adherence to treatment in a sample of patients with hypertension in the west Pomeranian Voivodeship of Poland.Frontiers in public health · 2025Article
- Cardiovascular medication adherence testing in patients living with HIV: A single-centre observational study.HIV medicine · 2024Observational
- Antihypertensive Medication Adherence and Medical Costs, Health Care Use, and Labor Productivity Among People With Hypertension.Journal of the American Heart Association · 2024Article
- Developing feedback visualizations to support older adults' medication adherence.Human factors in healthcare · 2024Article
- Management of Hypertension in the Asia-Pacific Region: A Structured Review.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2024Review
- Antihypertensive medication nonadherence and target organ damage in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2024Article
- Medication Adherence and Treatment-Resistant Hypertension in Newly Treated Hypertensive Patients in the United Arab Emirates.Journal of clinical medicine · 2021Article
- Nonadherence to antihypertensive medications amongst patients with uncontrolled hypertension: A retrospective study.Medicine · 2021Observational
- Adherence to antihypertensive medication and its predictors among non-elderly adults in Japan.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Group-Based Trajectory Modeling to Identify Patterns of Adherence and Its Predictors Among Older Adults on Angiotensin-Converting Enzyme Inhibitors (ACEIs)/Angiotensin Receptor Blockers (ARBs).Patient preference and adherence · 2020Article
- Adherence to Antihypertensive Treatment and Associated Factors in Central Ethiopia.International journal of hypertension · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate adherence to antihypertensive therapy (AHT) and the association between adherence to AHT, all-cause mortality, and cardiovascular (CV) morbidity in a large cohort of patients newly treated with antihypertensives in a clinical practice setting.
methodsAn administrative database kept by the Local Health Unit of Florence (Italy) listing patient baseline characteristics, drug prescription, and hospital admission information was used to perform a population-based retrospective study including patients newly treated with antihypertensives, ≥18 years of age, with a first prescription between January 1, 2004 and December 31, 2006. Patients using antihypertensives for secondary prevention of CV disease, occasional spot users, and patients with early CV events, were excluded from the study cohort. Adherence to AHT was calculated and classified as poor, moderate, good, and excellent. A Cox regression model was conducted to determine the association among adherence to AHT and risk of all-cause mortality, stroke, or acute myocardial infarction.
resultsA total of 31,306 patients, 15,031 men (48.0%), and 16,275 women (52.0%), with a mean age of 60.2 ± 14.5 years was included in the study. Adherence to AHT was poor in 8038 patients (25.7% of included patients), moderate in 4640 (14.8%), good in 5651 (18.1%), and excellent in 12,977 (41.5%). Compared with patients with poor adherence (hazard ratio [HR] = 1), the risk of all-cause death, stroke, or acute myocardial infarction was significantly lower in patients with good (HR = 0.69, P < 0.001) and excellent adherence (HR = 0.53, P < 0.001).
conclusionsThese findings indicate that suboptimal adherence to AHT occurs in a substantial proportion of patients and is associated with poor health outcomes already in primary prevention of CV diseases. For health authorities, this preliminary evidence underlines the need for monitoring and improving medication adherence in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.