Evidence map›Paper›PMID 21934905›Full record

ArticleOptics express2011

Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography.

Simon S Gao, Anping Xia, Tao Yuan, Patrick D Raphael, Ryan L Shelton, Brian E Applegate, John S Oghalai

Open access · goldAbstract read
In one paragraph

Article in Optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 53 citations in OpenAlex.

  1. Trial
  2. Quantitative Pneumatic Otoscopy Using a Light-Based Ranging Technique.Journal of the Association for Research in Otolaryngology : JARO · 2017
    Trial
  3. Article
  4. The State of High-Resolution Imaging of the Human Inner Ear: A Look Into the Black Box.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Otitis Media Middle Ear Effusion Identification and Characterization Using an Optical Coherence Tomography Otoscope.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2020
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Simon S GaoDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, 801 Welch Road, Stanford, CA 94305, USA.
Anping Xia
Tao Yuan
Patrick D Raphael
Ryan L Shelton
Brian E Applegate
John S Oghalai
Texas A&M University · USBaylor College of Medicine · USStanford University · US

Funding

Stanford OHNS Core CenterP30DC010363 · NIDCD · STANFORD UNIVERSITY · PI RICCI, ANTHONY J · 2009 to 2016
$3.0M
Modulation of Cochlear TuningK08DC006671 · NIDCD · BAYLOR COLLEGE OF MEDICINE · PI OGHALAI, JOHN S · 2004 to 2008
$839k
NIDCD NIH HHS K08 DC006671NIDCD NIH HHS P30 DC010363NIDCD NIH HHS P30DC010363
6 · The paper itself

Abstract

Human hearing loss often occurs as a result of damage or malformations to the functional soft tissues within the cochlea, but these changes are not appreciable with current medical imaging modalities. We sought to determine whether optical coherence tomography (OCT) could assess the soft tissue structures relevant to hearing using mouse models. We imaged excised cochleae with an altered tectorial membrane and during normal development. The soft tissue structures and expected anatomical variations were visible using OCT, and quantitative measurements confirmed the ability to detect critical changes relevant to hearing.

Indexed as

AnimalsCochleaDiagnostic ImagingDisease Models, AnimalEquipment DesignHearingHearing Loss, SensorineuralMagnetic Resonance ImagingMiceMice, TransgenicModels, AnatomicOptics and PhotonicsOrgan of CortiTomography, Optical CoherenceTomography, X-Ray Computed

Identifiers

PMID21934905
PMCPMC3482885
OpenAlexW2078226158

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.