ArticleNeuroscience bulletin2011
The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer's disease.
Article in Neuroscience bulletin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- A Quantitative Systems Pharmacology Model That Describes Neurofilament Light Dynamics During Alzheimer's Disease Progression.CPT: pharmacometrics & systems pharmacology · 2025Article
- White matter alterations and their associations with biomarkers and behavior in subjective cognitive decline individuals: a fixel-based analysis.Behavioral and brain functions : BBF · 2024Article
- NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport.Molecular neurodegeneration · 2024Article
- Pathophysiology of neurodegenerative diseases: An interplay among axonal transport failure, oxidative stress, and inflammation?Seminars in immunology · 2022Review
- Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease.Aging cell · 2021Article
- Article
- Cognitive improvements and reduction in amyloid plaque deposition by saikosaponin D treatment in a murine model of Alzheimer's disease.Experimental and therapeutic medicine · 2020Article
- Motor deficits are independent of axonopathy in an Alzheimer's disease mouse model of TgCRND8 mice.Oncotarget · 2017Article
- The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology.Cell reports · 2017Article
- Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders.Frontiers in neuroscience · 2017Review
- Relation between aerobic fitness and brain structures in amnestic mild cognitive impairment elderly.Age (Dordrecht, Netherlands) · 2016Article
- Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy.Annals of clinical and translational neurology · 2016Article
- Altered expression of neurofilament 200 and amyloid-β peptide (1-40) in a rat model of chronic cerebral hypoperfusion.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Article
- Tau hyperphosphorylation induces apoptotic escape and triggers neurodegeneration in Alzheimer's disease.Neuroscience bulletin · 2014Review
- Clusterin in Alzheimer's disease: a player in the biological behavior of amyloid-beta.Neuroscience bulletin · 2014Review
- Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation.Frontiers in aging neuroscience · 2014Article
- MicroRNA-98 induces an Alzheimer's disease-like disturbance by targeting insulin-like growth factor 1.Neuroscience bulletin · 2013Article
- The airbag problem-a potential culprit for bench-to-bedside translational efforts: relevance for Alzheimer's disease.Acta neuropathologica communications · 2013Review
- Deciphering the mechanism underlying late-onset Alzheimer disease.Nature reviews. Neurology · 2013Review
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe production of neurotoxic β-amyloid and the formation of hyperphosphorylated tau are thought to be critical steps contributing to the neuropathological mechanisms in Alzheimer's disease (AD). However, there remains an argument as to their importance in the onset of AD. Recent studies have shown that axonopathy is considered as an early stage of AD. However, the exact relationship between axonopathy and the origin and development of classic neuropathological changes such as senile plaques (SPs) and neurofibrillary tangles (NFTs) is unclear. The present study aimed to investigate this relationship.
methodsPostmortem tracing, combined with the immunohistochemical or immunofluorescence staining, was used to detect axonopathy and the formation of SPs and NFTs.
resultsAxonal leakage-a novel type of axonopathy, was usually accompanied with the extensive swollen axons and varicosities, and was associated with the origin and development of Aβ plaques and hyperphosphorylated tau in the brains of AD patients.
conclusionAxonopathy, particularly axonal leakage, might be a key event in the initiation of the neuropathological processes in AD.
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