ArticleEuropean journal of human genetics : EJHG2012
Involvement of surfactant protein D in emphysema revealed by genetic association study.
Article in European journal of human genetics : EJHG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Systematic Review and Meta-Analysis Confirms Significant Contribution of Surfactant Protein D in Chronic Obstructive Pulmonary Disease.Frontiers in genetics · 2019Pooled it
- Reply to the Letter to the Editor: Methodological considerations regarding the association between emphysema and pulmonary vascular volume heterogeneity.European radiology · 2026Article
- Pulmonary vascular volume heterogeneity in association with emphysema: a multicenter study based on non-contrast chest CT.European radiology · 2026Article
- Proteome-wide Mendelian randomisation of lung function to identify potential therapeutic targets for respiratory disease.ERJ open research · 2026Article
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- Surfactant Protein D in Respiratory and Non-Respiratory Diseases.Frontiers in medicine · 2018Review
- Human Surfactant Protein D Suppresses Epithelial-to-Mesenchymal Transition in Pancreatic Cancer Cells by Downregulating TGF-β.Frontiers in immunology · 2018Article
- Genetic Association of Pulmonary Surfactant Protein Genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD With Cystic Fibrosis.Frontiers in immunology · 2018Article
- Genetic studies as a tool for identifying novel potential targets for treatment of COPD.The European respiratory journal · 2017Article
- Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation.The European respiratory journal · 2017Article
- OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- A novel candidate region for genetic adaptation to high altitude in Andean populations.PloS one · 2015Article
- Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease.Respiratory research · 2014Review
- Genetic polymorphisms of surfactant protein D rs2243639, Interleukin (IL)-1β rs16944 and IL-1RN rs2234663 in chronic obstructive pulmonary disease, healthy smokers, and non-smokers.Molecular diagnosis & therapy · 2014Article
- Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms.BMC medical genetics · 2014Article
- Age-related increases in ozone-induced injury and altered pulmonary mechanics in mice with progressive lung inflammation.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Surfactant phospholipid metabolism.Biochimica et biophysica acta · 2013Review
- Updates on the COPD gene list.International journal of chronic obstructive pulmonary disease · 2012Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surfactant protein D (SFTPD) induces emphysema in knockout mice, but the association of SFTPD with chronic obstructive pulmonary disease (COPD) and emphysema in humans is unclear. Therefore, we aimed to determine the association between genetic variations in SFTPD and susceptibility to COPD and emphysema.Two populations were studied: population A comprised 270 smokers, including 188 COPD and 82 at-risk subjects, and population B comprised 1131 autopsy cases including 160 cases with emphysema. Six single-nucleotide polymorphisms (SNPs) that tagged the linkage disequilibrium blocks on the entire SFTPD gene were genotyped; the associations of the genotypes with COPD, pulmonary function, percentage of the low-attenuation area (LAA%), and percentage of the airway wall area (WA%) were determined in population A. In population B, the associations of the genotypes with emphysema were assessed.A C allele at SNP rs721917 that results in the replacement of Met with Thr at position 11 in SFTPD was positively correlated with the LAA% in the upper lung (P = 1.1 × 10(-5)) and overall LAA% (P = 1.0 × 10(-4)), and negatively correlated with the serum concentration of SFTPD (P = 7 × 10(-11)) in the population A. The C/C (rs721917/rs10887199) haplotype was associated with emphysema in both the populations.Subjects with a C allele at rs721917 have a lower serum SFTPD concentration and are more susceptible to emphysema. This suggests a protective effect of SFTPD against COPD and emphysema.
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Registered trials
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