Evidence map›Paper›PMID 21934474›Full record

Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2012

Mitigating cellular inflammation in older adults: a randomized controlled trial of Tai Chi Chih.

Michael R Irwin, Richard Olmstead

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 8 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 8 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Pooled it
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  4. A Meta-Analysis of the Effects of Different Exercise Modes on Inflammatory Response in the Elderly.International journal of environmental research and public health · 2022
    Pooled it
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  9. Trial
  10. Inflammatory Markers of Geriatric Depression Response to Tai Chi or Health Education Adjunct Interventions.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Trial
  11. A Randomized Controlled Trial of Tai Chi Chih or Health Education for Geriatric Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael R IrwinCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California, Los Angeles, CA 90095, USA. mirwin1@ucla.edu
Richard Olmstead
University of California, Los Angeles · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
Fellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3M
Aging: Sleep and Inflammatory Mechanisms in Depression PreventionR01AG026364 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2005 to 2015
$5.8M
Sleep and Immune Mechanisms in Rheumatoid ArthritisR01HL079955 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2009
$3.0M
Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune MechanismsR01CA119159 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2010
$2.2M
Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in AgR01AG034588 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2009 to 2013
$1.9M
Post-Graduate Training Program in Psychoneuroimmunology and Mental HealthT32MH019925 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 1997 to 2012
$1.7M
BEHAVIORAL INTERVENTION FOR HERPES ZOSTER RISK IN AGINGR01AG018367 · NIA · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI IRWIN, MICHAEL R · 2000 to 2003
$1.3M
TAI CHI CHIH AND VARICELLA ZOSTER IMMUNITYR21AT000255 · NCCIH · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI IRWIN, MICHAEL R · 2000 to 2001
$372k
NCATS NIH HHS UL1 TR000124NCCIH NIH HHS R21 AT000255NCCIH NIH HHS R21-AT00255NCI NIH HHS R01-CA 10014152NCI NIH HHS R01 CA119159NCRR NIH HHS M01 RR000865NCRR NIH HHS M01-RR00865NHLBI NIH HHS R01 HL 079955NHLBI NIH HHS R01 HL079955NIA NIH HHS P30 AG028748NIA NIH HHS P30-AG028748NIA NIH HHS R01 AG018367NIA NIH HHS R01 AG026364NIA NIH HHS R01-AG 026364NIA NIH HHS R01 AG034588NIA NIH HHS R01-AG 034588NIA NIH HHS R01-AG 18367NIMH NIH HHS T32 MH018399NIMH NIH HHS T32 MH019925NIMH NIH HHS T32-MH18399
6 · The paper itself

Abstract

objectivesTo evaluate the effects of a behavioral intervention, Tai Chi Chih (TCC) on circulating markers of inflammation in older adults.

designA prospective, randomized, controlled trial with allocation to two arms, TCC and health education (HE), 16 weeks of intervention administration, and 9 weeks follow-up.

participantsA total of 83 healthy older adults, aged 59 to 86 years. MEASUREMENTS: The primary endpoint was circulating levels of interleukin 6 (IL-6). Secondary outcomes were circulating levels of C-reactive protein, soluble IL-1 receptor antagonist, soluble IL-6 receptor, soluble intercellular adhesion molecule, and IL-18. Severity of depressive symptoms, sleep quality, and physical activity was also assessed over the treatment trial.

resultsAmong those older adults with high levels of IL-6 at entry, a trend for a treatment group by time interaction was found (F[1,70] = 3.48, p = 0.07), in which TCC produced a drop of IL-6 levels comparable to those found in TCC and HE subgroups who had low levels of IL-6 at entry (t72's = 0.80, 1.63, p's >0.10), whereas IL-6 in HE remained higher than the TCC and HE subgroups with low entry IL-6 (t72 = 2.47, p = 0.02; t72 = 1.71, p = 0.09). Decreases in depressive symptoms in the two treatment groups correlated with decreases of IL-6 (r = 0.28, p <0.05). None of the other cellular markers of inflammation changed in TCC versus HE.

conclusionTCC can be considered a useful behavioral intervention to reduce circulating levels of IL-6 in older adults who show elevated levels of this inflammatory marker and are at risk for inflammation-related morbidity.

Indexed as

AgedAged, 80 and overAge FactorsBiomarkersC-Reactive ProteinDepressionFemaleHumansInflammationIntercellular Adhesion Molecule-1Interleukin-18Interleukin 1 Receptor Antagonist ProteinInterleukin-6MaleMiddle AgedMotor ActivityBiomarkersC-Reactive ProteinIntercellular Adhesion Molecule-1Interleukin-18Interleukin 1 Receptor Antagonist ProteinInterleukin-6Receptors, Interleukin-6

Identifiers

PMID21934474
PMCPMC3247625
OpenAlexW2046838557

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.