ArticleKidney & blood pressure research2012
Serum vitamin D level and prehypertension among subjects free of hypertension.
Article in Kidney & blood pressure research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Serum Vitamin D Levels in Relation to Hypertension and Pre-hypertension in Adults: A Systematic Review and Dose-Response Meta-Analysis of Epidemiologic Studies.Frontiers in nutrition · 2022Pooled it
- Vitamin - D deficiency as a risk factor in primary hypertension - A cross sectional study.Bioinformation · 2025Article
- Vitamin D Deficiency Is a Potential Risk for Blood Pressure Elevation and the Development of Hypertension.Medicina (Kaunas, Lithuania) · 2021Article
- Vitamin D deficiency and essential hypertension.Journal of the American Society of Hypertension : JASH · 2015Review
- Potential pathophysiological role for the vitamin D deficiency in essential hypertension.World journal of cardiology · 2014Review
- Does vitamin D modulate blood pressure?Current opinion in nephrology and hypertension · 2013Review
- Vitamin D and cardiovascular risk.Current hypertension reports · 2012Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundLow serum vitamin D levels are associated with high blood pressure (BP). Prehypertension is a preclinical stage where primary prevention efforts have been recommended for delaying or preventing the onset of hypertension. However, the majority of studies examining the association between vitamin D and BP have not accounted for kidney function or systemic inflammation.
methodsParticipants of the 3rd National Health and Nutrition Examination Survey > 20 years of age and free of hypertension (n = 9,215, 53.5% women) and clinical cardiovascular disease were examined. Serum vitamin D levels were analyzed as quartiles. Prehypertension (n = 3,712) was defined as systolic BP 120-139 mm Hg or diastolic BP 80-89 mm Hg.
resultsLower serum vitamin D levels were found to be associated with prehypertension independent of potential confounders including body mass index (BMI), serum cholesterol, C-reactive protein and estimated glomerular filtration rate. Compared to the highest quartile of serum vitamin D (referent), the odds ratio (95% confidence interval) of prehypertension associated with the lowest quartile was 1.48 (1.16-1.90; p trend < 0.0001). This association persisted in subgroup analyses by gender, race-ethnicity and BMI.
conclusionLower serum vitamin D levels are associated with prehypertension in a representative sample of US adults.
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Registered trials
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