ArticleCarcinogenesis2011
A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous cell carcinoma of the head and neck.
Article in Carcinogenesis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Susceptibility ofTechnology in cancer research & treatmentPooled it
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- Genetic polymorphisms of PGF and TNFAIP2 genes related to cervical cancer risk among Uygur females from China.BMC medical genetics · 2020Article
- Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects.OncoTargets and therapy · 2020Review
- Correlation Between TNFAIP2 Gene Polymorphism and Prediction/Prognosis for Gastric Cancer and Its Effect on TNFAIP2 Protein Expression.Frontiers in oncology · 2020Article
- The chaperone ERp29 is required for tunneling nanotube formation by stabilizing MSec.The Journal of biological chemistry · 2019Article
- Differential expression of snoRNAs in oral squamous cell carcinomas: new potential diagnostic markers.Journal of enzyme inhibition and medicinal chemistry · 2018Article
- The roles of TNFAIP2 in cancers and infectious diseases.Journal of cellular and molecular medicine · 2018Review
- Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck.Molecular carcinogenesis · 2018Article
- Profile of the breast cancer susceptibility marker rs4245739 identifies a role for miRNAs.Cancer biology & medicine · 2017Article
- Genome-scale identification of microRNA-related SNPs associated with risk of head and neck squamous cell carcinoma.Carcinogenesis · 2017Article
- Levels of MicroRNA Heterogeneity in Cancer Biology.Molecular diagnosis & therapy · 2017Review
- Overexpression of miR-584-5p inhibits proliferation and induces apoptosis by targeting WW domain-containing E3 ubiquitin protein ligase 1 in gastric cancer.Journal of experimental & clinical cancer research : CR · 2017Article
- Polymorphism (rs16917496) at the miR-502 Binding Site of the Lysine Methyltransferase 5A (Advanced biomedical research · 2017Article
- Genetic variants within microRNA-binding site of RAD51B are associated with risk of cervical cancer in Chinese women.Cancer medicine · 2016Article
- A variant at a potentially functional microRNA-binding site in BRIP1 was associated with risk of squamous cell carcinoma of the head and neck.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- TNFAIP2 Inhibits Early TNFα-Induced NF-x03BA;B Signaling and Decreases Survival in Septic Shock Patients.Journal of innate immunity · 2016Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Although the role of TNFAIP2 is still unclear, it is an important gene involved in apoptosis, and there are single-nucleotide polymorphisms (SNPs) at its microRNA (miRNA)-binding sites that could modulate miRNA target gene function. In this study, we evaluated associations of four selected SNPs (rs8126 T > C, rs710100 G > A, rs1052912 G > A and rs1052823 G > T) in the miRNA-binding sites of the 3' untranslated region (UTR) with squamous cell carcinoma of the head and neck (SCCHN) risk in 1077 patients with SCCHN and 1073 cancer-free controls in a non-Hispanic White population. We found that, compared with the rs8126 TT genotype, the variant C allele were associated with increased SCCHN risk in an allele dose-response manner (adjusted odds ratio = 1.48 and 95% confidence interval = 1.06-2.05 for CC, respectively; P(trend) = 0.009). No significant associations were seen for the other three SNPs (rs710100 G > A, rs1052912 G > A and rs1052823 G > T). Additionally, we identified that the rs8126 T > C SNP is within the miR-184 seed binding region in the 3' UTR of TNFAIP2. Further functional analyses showed that the rs8126 variant C allele led to significantly lower luciferase activity, compared with the T allele. In the genotype-phenotype correlation analysis of peripheral blood mononuclear cells from 64 SCCHN patients, the rs8126 CC genotype was associated with reduced expression of TNFAIP2 messenger RNA. Taken together, these findings indicate that the miR-184 binding site SNP (rs8126 T > C) in the 3' UTR of TNFAIP2 is functional by modulating TNFAIP2 expression and contributes to SCCHN susceptibility. Larger replication studies are needed to confirm our findings.
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