ArticleJournal of leukocyte biology2011
Investigation of the differential potentials of TLR agonists to elicit uveitis in mice.
Article in Journal of leukocyte biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Ocular Microbiota and Intraocular Inflammation.Frontiers in immunology · 2020Pooled it
- TLR4 deficiency does not alter glaucomatous progression in a mouse model of chronic glaucoma.Scientific reports · 2025Article
- Inhibiting TLR7 Expression in the Retinal Pigment Epithelium Suppresses Experimental Autoimmune Uveitis.Frontiers in immunology · 2021Article
- The microbiome and HLA-B27-associated acute anterior uveitis.Nature reviews. Rheumatology · 2018Review
- Toll-like receptors 4, 5, 6 and 7 are constitutively expressed in non-human primate retinal neurons.Journal of neuroimmunology · 2018Article
- Augmenting Endogenous Levels of Retinal Annexin A1 Suppresses Uveitis in Mice.Translational vision science & technology · 2017Article
- Effect of glucocorticoid on cytokines TLR9 and TLR7 in peripheral blood for patients with uveitis.Experimental and therapeutic medicine · 2016Article
- Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model.Disease models & mechanisms · 2016Article
- Aqueous humor cytokine profiling in patients with wet AMD.Molecular vision · 2016Article
- Anti-inflammatory effect of Heliotropium indicum Linn on lipopolysaccharide-induced uveitis in New Zealand white rabbits.International journal of ophthalmology · 2016Article
- Unexpected Roles for Toll-Like Receptor 4 and TRIF in Intraocular Infection with Gram-Positive Bacteria.Infection and immunity · 2015Article
- Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity.Science translational medicine · 2015Article
- Role of toll-like receptors in human iris pigment epithelial cells and their response to pathogen-associated molecular patterns.Journal of inflammation (London, England) · 2014Article
- Investigation of the peptidoglycan sensing molecule, PGLYRP-2, in murine inflammatory uveitis.The British journal of ophthalmology · 2013Article
- Bacterial endophthalmitis in the age of outpatient intravitreal therapies and cataract surgeries: host-microbe interactions in intraocular infection.Progress in retinal and eye research · 2012Review
- Article
- Aberrant interleukin-1 signalling does not increase susceptibility of mice to NOD2-dependent uveitis.Clinical & experimental ophthalmologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
TLRs are critical for host defense and innate immunity. Emerging evidence also supports a role for TLRs in many chronic inflammatory diseases, including inflammatory eye disease, known as uveitis. The activation of TLR4 by endotoxin induces a standard model of murine uveitis. How activation of additional TLRs influences the onset and/or severity of anterior uveitis has not been examined. We sought to elucidate the potential of TLRs (TLR1/2, TLR2/6, TLR3, TLR4, TLR5, TLR7/8, and TLR9) to trigger uveitis in mice. Directly stimulated iris/ciliary body explants demonstrated a marked increase in production of inflammatory cytokines TNF-α, IL-6, IP-10/CXCL10, MCP-1, and KC with relatively little production of IFN-γ, IL-10, IL-12p40, IL-12p70, IL-17, IL-1β, IL-4, or RANTES. The cytokine-response profiles were comparable amongst the TLR agonists, albeit some differences were noted, such as greater IP-10 production following TLR3 activation. Intra-ocular injection of TLR agonists increased leukocyte interactions with the endothelium of the iris vasculature and resulted in chemotaxis into the iris tissue. Assessment of leukocytic responses by ivt videomicroscopy and histology revealed quantitative differences amongst responses to the TLR agonists with respect to the timing and numbers of rolling, adhering, iris-infiltrating, and aqueous humor-infiltrating cells, along with cytokine levels in vivo. Our data demonstrate the eye's responsiveness to a diverse array of microbial products, which activates TLRs, and reveal differences in relative cellular response among the various TLR agonists in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.