ArticlemBio2011
Stress-induced loss of heterozygosity in Candida: a possible missing link in the ability to evolve.
Article in mBio, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens.BMC biology · 2023Article
- Clonal evolution ofJournal of oral microbiology · 2021Article
- Characterization of aJournal of fungi (Basel, Switzerland) · 2020Article
- Dynamic Extreme Aneuploidy (DEA) in the vegetable pathogen Phytophthora capsici and the potential for rapid asexual evolution.PloS one · 2020Article
- Mechanisms of genome evolution in Candida albicans.Current opinion in microbiology · 2019Review
- Genetic and Genome Analyses Reveal Genetically Distinct Populations of the Bee Pathogen Nosema ceranae from Thailand.Microbial ecology · 2019Article
- Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Characterization of Salt-Induced Epigenetic Segregation by Genome-Wide Loss of Heterozygosity and its Association with Salt Tolerance in Rice (Frontiers in plant science · 2017Article
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- Stress-induced mutation via DNA breaks in Escherichia coli: a molecular mechanism with implications for evolution and medicine.BioEssays : news and reviews in molecular, cellular and developmental biology · 2012Article
- Genome sequencing and mapping reveal loss of heterozygosity as a mechanism for rapid adaptation in the vegetable pathogen Phytophthora capsici.Molecular plant-microbe interactions : MPMI · 2012Article
- Germ cell proteins in melanoma: prognosis, diagnosis, treatment, and theories on expression.Journal of skin cancer · 2012Article
- What limits the efficiency of double-strand break-dependent stress-induced mutation in Escherichia coli?Journal of molecular microbiology and biotechnology · 2011Article
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1 author at 1 institution in 1 country.
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Abstract
Diploid organisms are buffered against the effects of mutations by carrying two sets of each gene, which allows compensation if one is mutated. But recombination between "mom" and "dad" chromosomes causes loss of heterozygosity (LOH), stretches of "mom-only" or "dad-only" DNA sequence, suddenly revealing effects of mutations accumulated in entire chromosome arms. LOH creates new phenotypes from old mutations, drives cancer development and evolution, and, in a new study by Forche et al., is shown to be induced by stress in Candida albicans [Forche A, et al, mBio 2(4):e00129-11, 2011]. Stress-induced LOH could speed evolution of Candida specifically when it is poorly adapted to its environment. Moreover, the findings may provide a missing link between recombination-dependent mutagenesis in bacteria and yeast, suggesting that both might be stress induced, both maximizing genetic variation when populations could benefit most from diversity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.